{"title":"神经胶质瘤图像分析准确分类Mgmt和预测药物有效性","authors":"V. Mehta","doi":"10.47363/jcbr/2021(3)128","DOIUrl":null,"url":null,"abstract":"Glioblastoma multiforme is a deadly brain cancer with a median patient survival time of 18-24 months. A single biopsy cannot provide complete assessment of the tumor’s microenvironment, making personalized care limited. 50% of the patients do not respond to the anti-cancer drug Temozolomide(TMZ) because of the over-expression of MGMT gene. Epigenetic silencing of the MGMT gene by methylation results in decreased MGMT expression, resulting in increased sensitivity to TMZ, and longer survival. The purpose of this research is to use artificial intelligence (AI) to design a low cost methodology to determine the MGMT’s methylation status and suggest non- invasive treatment plan","PeriodicalId":15099,"journal":{"name":"Journal of Biomedical and Clinical Research","volume":"133 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Glioma Image Analysis to Accurately Classify Mgmt and Predict Drug Effectiveness\",\"authors\":\"V. Mehta\",\"doi\":\"10.47363/jcbr/2021(3)128\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Glioblastoma multiforme is a deadly brain cancer with a median patient survival time of 18-24 months. A single biopsy cannot provide complete assessment of the tumor’s microenvironment, making personalized care limited. 50% of the patients do not respond to the anti-cancer drug Temozolomide(TMZ) because of the over-expression of MGMT gene. Epigenetic silencing of the MGMT gene by methylation results in decreased MGMT expression, resulting in increased sensitivity to TMZ, and longer survival. The purpose of this research is to use artificial intelligence (AI) to design a low cost methodology to determine the MGMT’s methylation status and suggest non- invasive treatment plan\",\"PeriodicalId\":15099,\"journal\":{\"name\":\"Journal of Biomedical and Clinical Research\",\"volume\":\"133 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biomedical and Clinical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47363/jcbr/2021(3)128\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomedical and Clinical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47363/jcbr/2021(3)128","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Glioma Image Analysis to Accurately Classify Mgmt and Predict Drug Effectiveness
Glioblastoma multiforme is a deadly brain cancer with a median patient survival time of 18-24 months. A single biopsy cannot provide complete assessment of the tumor’s microenvironment, making personalized care limited. 50% of the patients do not respond to the anti-cancer drug Temozolomide(TMZ) because of the over-expression of MGMT gene. Epigenetic silencing of the MGMT gene by methylation results in decreased MGMT expression, resulting in increased sensitivity to TMZ, and longer survival. The purpose of this research is to use artificial intelligence (AI) to design a low cost methodology to determine the MGMT’s methylation status and suggest non- invasive treatment plan
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