人工手性纳米通道

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Supramolecular Chemistry Pub Date : 2021-06-03 DOI:10.1080/10610278.2021.1991924

Q. He, Mingjie Tao, Wajahat Ali, Xuehong Min, Yanxi Zhao

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引用次数: 0

摘要

具有手性特征的生物通道能够智能调节物质在细胞膜中的转运，在维持生物体的正常功能中起着至关重要的作用。然而，生物纳米通道的高度复杂性和可变性是实际研究的主要制约因素。目前，人造固态通道已经发展到模拟生物通道的功能。这些官能团通常被引入到纳米通道中，以实现分子的选择性传感和转运。特别是在人工手性纳米通道的开发方面取得了快速的进展。本文综述了利用手性大环宿主、氨基酸和无标记方法构建人工手性纳米通道的最新进展，以期为超分子化学、手性化学和药物开发等领域的研究人员提供支持。图形抽象

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Artificial chiral nanochannels

ABSTRACT The biological channels with chiral features are capable of intelligently regulating substance transport through cell membrane, which plays a pivotal role in maintaining normal functions for living organisms. However, the high complexity and variability of biological nanochannels are the major constraints on practical studies. At present, artificial solid-state channels have been developed to simulate the functionality of biological channels. The functional groups are often introduced into nanochannels to achieve selective sensing and transport molecules. In particular, the fast-paced progress has been made in developing artificial chiral nanochannels. This review highlights the recent advancement of artificial chiral nanochannels as constructed using various strategies, including chiral macrocyclic hosts, amino acids, and label-free methods, which are expected to support the researchers working in fields such as supramolecular chemistry, chiral chemistry, and drug development. Graphical Abstract

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来源期刊

Supramolecular Chemistry 化学-化学综合

CiteScore

3.60

自引率

3.00%

发文量

审稿时长

2.7 months

期刊介绍： Supramolecular Chemistry welcomes manuscripts from the fields and sub-disciplines related to supramolecular chemistry and non-covalent interactions. From host-guest chemistry, self-assembly and systems chemistry, through materials chemistry and biochemical systems, we interpret supramolecular chemistry in the broadest possible sense. Interdisciplinary manuscripts are particularly encouraged. Manuscript types include: high priority communications; full papers; reviews, and; Methods papers, techniques tutorials highlighting procedures and technologies that are important to the field. We aim to publish papers in a timely fashion and as soon as a paper has been accepted and typeset it will be published in electronic form on the Latest articles section of the website. The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field. Under normal circumstances, Supramolecular Chemistry does not consider manuscripts that would be more suitable in a highly specialized journal. This includes, but is not limited to, those based mostly or exclusively on topics such as solid state/X-ray structures, computational chemistry, or electrochemistry. . The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field.