致死性职业性硒代蛋氨酸中毒伴危害反应1例报告

H. Spiller, Judd Shelton, A. Funk
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引用次数: 1

摘要

一名30岁男性在测量硒代蛋氨酸时职业性暴露。他因恶心、虚弱和呕吐而离开了工作岗位。他在家里洗了澡,换了衣服。由于症状持续恶化,在接触4小时后,他被送往紧急护理中心(UCC),在那里他立即被救护车送往急诊室(ED)。UCC和急诊室的工作人员注意到他有一种强烈的有毒化学气味。患者病情迅速恶化,需要插管和100% O2 PEEP。给予纳洛酮、葡萄糖、碳酸氢盐、液体复苏和多巴胺输注。到达后20分钟,患者出现心脏骤停。复苏没有成功。死后血硒浓度为11000µg/L。一个多部门的危险品调查就此展开。UCC和病人的家都被封锁了。24名工作人员被隔离7小时。UCC的八名员工接受了消毒并被送往急诊室进行评估。家属和立即响应的官员被隔离在现场。由呼吸和汗液排出的挥发性甲基化形式的硒,而不是残留的硒代蛋氨酸粉末,可能导致了急诊室工作人员报告的化学气味。急诊科人员的二次污染是有症状的病人在接触化学物质后自我表现的风险。在病人洗澡和换衣服后,急诊室人员不太可能受到粉状物质的二次污染,但考虑到当时的未知性质,危险事件指挥官可能决定采取充分的预防措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fatal occupational selenomethionine poisoning with hazmat response: a case report
Abstract A 30-year-old male had an occupational exposure while measuring selenomethionine. He left work due to onset of nausea, weakness and vomiting. He showered and changed clothes at home. Due to continued worsening of symptoms, four hours post-exposure he was brought to an urgent care center (UCC), where he was immediately transported via ambulance to an emergency department (ED). He was noted by UCC and ED staff to have a strong noxious chemical odor. The patient deteriorated rapidly requiring intubation, and PEEP with 100% O2. Naloxone, dextrose, bicarbonate, fluid resuscitation and dopamine infusion were administered. Twenty minutes after arrival, the patient experienced asystole. Resuscitation was not successful. Postmortem blood selenium concentration was 11,000 µg/L. A multi-agency hazmat investigation occurred. The UCC and the patient’s home were locked down. Twenty-four personnel were quarantined on-site for 7 h. Eight employees of the UCC underwent decontamination and transport to an ED for evaluation. Family members and immediate responding officers were quarantined on-site. Volatile methylated forms of selenium excreted in breath and sweat and not residual selenomethionine powder likely caused the chemical odor reported by the ED staff. Secondary contamination of ED personnel is a risk from self-presentation by symptomatic patients after a chemical exposure. Secondary contamination of ED personnel is unlikely from a powdered substance after presentation of a patient who has showered and changed clothes but given the unknown nature at the time, Hazmat Incident Commanders may decide to exercise an abundance of precaution.
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