Minhua Xu, Ningping Huang, Zhongdang Xiao, Zuhong Lu
{"title":"光激发TiO2纳米粒子通过•oh自由基诱导恶性细胞坏死","authors":"Minhua Xu, Ningping Huang, Zhongdang Xiao, Zuhong Lu","doi":"10.1016/S0968-5677(98)00048-0","DOIUrl":null,"url":null,"abstract":"<div><p>Photoexcited TiO<sub>2</sub> nanoparticles have been used to cause oxidative stress in SPC-A1 lung adenocarcinoma cells in this study. It is commonly considered that hydroxyl free radicals can oxidatively stress cells to apoptosis, but through this experiment, we found that oxidative stress produced by photoexcited TiO<sub>2</sub> nanoparticles in the malignant cells led to cell necrosis, not, as it is thought, apoptosis. This was confirmed by TEM observation and DNA electrophoresis analysis. The possible mechanism of oxidative-stress-induced necrosis by photoexcited TiO<sub>2</sub> nanoparticles was discussed. The research revealed a novel possible way to kill tumor cells in the future.</p></div>","PeriodicalId":22050,"journal":{"name":"Supramolecular Science","volume":"5 5","pages":"Pages 449-451"},"PeriodicalIF":0.0000,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0968-5677(98)00048-0","citationCount":"32","resultStr":"{\"title\":\"Photoexcited TiO2 nanoparticles through •OH-radicals induced malignant cells to necrosis\",\"authors\":\"Minhua Xu, Ningping Huang, Zhongdang Xiao, Zuhong Lu\",\"doi\":\"10.1016/S0968-5677(98)00048-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Photoexcited TiO<sub>2</sub> nanoparticles have been used to cause oxidative stress in SPC-A1 lung adenocarcinoma cells in this study. It is commonly considered that hydroxyl free radicals can oxidatively stress cells to apoptosis, but through this experiment, we found that oxidative stress produced by photoexcited TiO<sub>2</sub> nanoparticles in the malignant cells led to cell necrosis, not, as it is thought, apoptosis. This was confirmed by TEM observation and DNA electrophoresis analysis. The possible mechanism of oxidative-stress-induced necrosis by photoexcited TiO<sub>2</sub> nanoparticles was discussed. The research revealed a novel possible way to kill tumor cells in the future.</p></div>\",\"PeriodicalId\":22050,\"journal\":{\"name\":\"Supramolecular Science\",\"volume\":\"5 5\",\"pages\":\"Pages 449-451\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0968-5677(98)00048-0\",\"citationCount\":\"32\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Supramolecular Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0968567798000480\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Supramolecular Science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0968567798000480","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Photoexcited TiO2 nanoparticles through •OH-radicals induced malignant cells to necrosis
Photoexcited TiO2 nanoparticles have been used to cause oxidative stress in SPC-A1 lung adenocarcinoma cells in this study. It is commonly considered that hydroxyl free radicals can oxidatively stress cells to apoptosis, but through this experiment, we found that oxidative stress produced by photoexcited TiO2 nanoparticles in the malignant cells led to cell necrosis, not, as it is thought, apoptosis. This was confirmed by TEM observation and DNA electrophoresis analysis. The possible mechanism of oxidative-stress-induced necrosis by photoexcited TiO2 nanoparticles was discussed. The research revealed a novel possible way to kill tumor cells in the future.
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