Turmimax®抗炎潜能的体内和体外研究

Q4 Biochemistry, Genetics and Molecular Biology
Firoz Hussain H M., N. S., S. Thimmegowda, Neethu Benny, R. Y.
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引用次数: 0

摘要

本研究的主要目的是研究Turmimax®生物增强姜黄制剂的体内和体外抗炎作用。通过比较刺激小鼠Raw 264.7巨噬细胞中白细胞介素-8 (Interleukin-8)和白细胞介素-12 (Interleukin-12)细胞因子的相对荧光强度,评价Turmimax®的体外抗炎效果。Turmimax®以100和200 mg/kg两种剂量口服,以评估其对巴豆油诱导的小鼠耳水肿和组胺诱导的白化大鼠足水肿的体内抗炎作用。双氯芬酸钠10mg /kg p.o.为标准用药。结果表明,Turmimax®显著且剂量依赖性地降低了炎症介质白介素-8和IL-12的产生。根据目前的研究结果,Turmimax®已显示出强大的抗炎作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Anti-Inflammatory Potential of Turmimax® an in vivo and in vitro Study
: The main objective of this study was to investigate the in vivo and in vitro anti-inflammatory effects of the Turmimax ® bio-enhanced turmeric formulation. By comparing the relative fluorescence intensities of the interleukins IL-8 (Interleukin-8) and IL-12 (Interleukin-12) cytokines in stimulated murine Raw 264.7 macrophages, Turmimax ® was evaluated for its anti-inflammatory in vitro efficacy. Turmimax ® was administered orally in two doses, 100 and 200 mg/kg, to assess its in vivo anti-inflammatory potential in ear edema induced by croton oil in mice and paw edema induced by histamine in albino rats. Diclofenac sodium 10 mg/kg p.o. is the standard drug. The results demonstrated that Turmimax ® significantly and dose-dependently decreased the production of the inflammatory mediator’s interleukin-8 and IL-12. According to the current investigation results, Turmimax ® has shown strong anti-inflammatory effects.
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来源期刊
American Journal of Biochemistry and Biotechnology
American Journal of Biochemistry and Biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
0.70
自引率
0.00%
发文量
27
期刊介绍: :: General biochemistry :: Patho-biochemistry :: Evolutionary biotechnology :: Structural biology :: Molecular and cellular biology :: Molecular medicine :: Cancer research :: Virology :: Immunology :: Plant molecular biology and biochemistry :: Experimental methodologies
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