{"title":"儿童机械通气患者气管淀粉酶与呼吸机相关性肺炎的相关性","authors":"K. Sitthikool, Sasitorn Supasad","doi":"10.33425/2689-1085.1018","DOIUrl":null,"url":null,"abstract":"Introduction: To determine the correlation between tracheal amylase level and ventilator-associated pneumonia (VAP); and evaluate whether tracheal amylase level is associated with pre-intubation aspiration risk factors. Methods: This was a cohort study at Queen Sirikit National Institute of Child Health, Bangkok, Thailand, during April 2019 – March 2020. Intubated and mechanically ventilated pediatric patients aged 1mo – 15 years were included. Tracheal amylase levels were measured at time of enrollment and day of suspected VAP. Results: Tracheal amylase levels were measured at the time of enrollment and on the day of suspected VAP diagnosis. Eighty-eight patients were enrolled in this study, 22 (25%) of which were diagnosed as VAP; and 56 (63.6%) were male. Median initial amylase levels in non-VAP and VAP groups were 165.5 U/L and 108.5 U/L respectively (p=0.82). Median amylase level when VAP was diagnosed decreased to 63 U/L. Median initial amylase level significantly increased in patients with pre-intubation risk factors for aspiration compared to those without (320 U/L and 56 U/L respectively, p < 0.001). Conclusions: There was no association between initial tracheal amylase level and VAP but increased tracheal amylase level was associated with pre-intubation risk factors for aspiration.","PeriodicalId":75037,"journal":{"name":"The Internet journal of pediatrics and neonatology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation of Tracheal Amylase and Ventilator-Associated Pneumonia in Mechanically Ventilated Pediatric Patients\",\"authors\":\"K. Sitthikool, Sasitorn Supasad\",\"doi\":\"10.33425/2689-1085.1018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: To determine the correlation between tracheal amylase level and ventilator-associated pneumonia (VAP); and evaluate whether tracheal amylase level is associated with pre-intubation aspiration risk factors. Methods: This was a cohort study at Queen Sirikit National Institute of Child Health, Bangkok, Thailand, during April 2019 – March 2020. Intubated and mechanically ventilated pediatric patients aged 1mo – 15 years were included. Tracheal amylase levels were measured at time of enrollment and day of suspected VAP. Results: Tracheal amylase levels were measured at the time of enrollment and on the day of suspected VAP diagnosis. Eighty-eight patients were enrolled in this study, 22 (25%) of which were diagnosed as VAP; and 56 (63.6%) were male. Median initial amylase levels in non-VAP and VAP groups were 165.5 U/L and 108.5 U/L respectively (p=0.82). Median amylase level when VAP was diagnosed decreased to 63 U/L. Median initial amylase level significantly increased in patients with pre-intubation risk factors for aspiration compared to those without (320 U/L and 56 U/L respectively, p < 0.001). Conclusions: There was no association between initial tracheal amylase level and VAP but increased tracheal amylase level was associated with pre-intubation risk factors for aspiration.\",\"PeriodicalId\":75037,\"journal\":{\"name\":\"The Internet journal of pediatrics and neonatology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-03-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet journal of pediatrics and neonatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33425/2689-1085.1018\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet journal of pediatrics and neonatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33425/2689-1085.1018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
前言:探讨气管淀粉酶水平与呼吸机相关性肺炎(VAP)的相关性;评估气管淀粉酶水平是否与插管前误吸危险因素相关。方法:这是一项队列研究,于2019年4月至2020年3月在泰国曼谷诗丽吉王后国立儿童健康研究所进行。包括年龄在1个月至15岁的插管和机械通气的儿童患者。在入组时和疑似VAP当日测量气管淀粉酶水平。结果:分别在入组时和疑似VAP诊断当日测量气管淀粉酶水平。88例患者入组,其中22例(25%)诊断为VAP;男性56例(63.6%)。非VAP组和VAP组初始淀粉酶水平中位数分别为165.5 U/L和108.5 U/L (p=0.82)。诊断为VAP时的中位淀粉酶水平降至63 U/L。插管前有误吸危险因素的患者初始淀粉酶水平中位数显著高于无危险因素的患者(分别为320 U/L和56 U/L, p < 0.001)。结论:气管初始淀粉酶水平与VAP无相关性,但气管淀粉酶水平升高与插管前误吸危险因素相关。
Correlation of Tracheal Amylase and Ventilator-Associated Pneumonia in Mechanically Ventilated Pediatric Patients
Introduction: To determine the correlation between tracheal amylase level and ventilator-associated pneumonia (VAP); and evaluate whether tracheal amylase level is associated with pre-intubation aspiration risk factors. Methods: This was a cohort study at Queen Sirikit National Institute of Child Health, Bangkok, Thailand, during April 2019 – March 2020. Intubated and mechanically ventilated pediatric patients aged 1mo – 15 years were included. Tracheal amylase levels were measured at time of enrollment and day of suspected VAP. Results: Tracheal amylase levels were measured at the time of enrollment and on the day of suspected VAP diagnosis. Eighty-eight patients were enrolled in this study, 22 (25%) of which were diagnosed as VAP; and 56 (63.6%) were male. Median initial amylase levels in non-VAP and VAP groups were 165.5 U/L and 108.5 U/L respectively (p=0.82). Median amylase level when VAP was diagnosed decreased to 63 U/L. Median initial amylase level significantly increased in patients with pre-intubation risk factors for aspiration compared to those without (320 U/L and 56 U/L respectively, p < 0.001). Conclusions: There was no association between initial tracheal amylase level and VAP but increased tracheal amylase level was associated with pre-intubation risk factors for aspiration.