长链非编码rna SNHG15在肿瘤中的表达及机制

国际肿瘤学杂志 Pub Date : 2019-06-18 DOI:10.3760/CMA.J.ISSN.1673-422X.2019.06.006

Yingying Li

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引用次数: 0

摘要

小核仁RNA宿主基因15 (SNHG15)是一类长链非编码RNA (lncRNAs)，位于7号染色体上。近年来研究表明，lncRNA SNHG15在胶质瘤、甲状腺癌、乳腺癌、肺癌、胃癌、结直肠癌、肝癌、肾癌、胰腺癌、骨肉瘤等各类癌症中均存在过表达，通过不同的信号通路促进恶性肿瘤的增殖、侵袭、转移，导致肿瘤患者预后不良。关键词:RNA，长链非编码;肿瘤;小核仁RNA宿主基因15

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Expression and mechanisms of long non-coding RNAs SNHG15 in cancers

As a kind of long non-coding RNAs (lncRNAs), small nucleolar RNA host gene 15 (SNHG15) is located on chromosome 7. In recent years, studies have shown that lncRNA SNHG15 is over expressed in various types of cancers such as glioma, thyroid cancer, breast cancer, lung cancer, gastric cancer, colorectal cancer, liver cancer, renal carcinoma, pancreatic cancer, osteosarcoma, and it can promote the proliferation, invasion, metastasis of malignant tumors and lead to poor prognosis of tumor patients through different signal pathways. Key words: RNA, long noncoding; Neoplasms; Small nucleolar RNA host gene 15

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国际肿瘤学杂志

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