The effect of perioperative magnesium sulphate on the total anesthetic and analgesic requirement in neck surgery

Background: The major perioperative goal is to provide adequate depth of anaesthesia along with optimum perioperative analgesia. One of the IV adjuvant that has been shown potential in pre-emptive analgesia is magnesium sulphate. This study was designed to assess the effect of perioperatively administered IV magnesium sulphate on anaesthetic and analgesic requirements. Materials And Methods: Sixty patients of ASA class 1, 2, 18-65 years of age scheduled for neck surgeries were randomly divided in to two groups. Group M received 40 mg/kg, magnesium sulphate in 100ml normal saline as loading dose over 20min followed by 8 mg/kg/hour as infusion till the end of the surgery during total intravenous anaesthesia with propofol, fentanyl and atracurium in neck surgeries. Group C received 100 ml normal saline as loading dose over 20min and thereafter continuous infusion of same volume of normal saline as received by group M. We observed total requirement of inj.propofol and inj.atracurium intraoperatively and duration of postoperative analgesia in both the groups. Results: The mean VAS score was consistently high in Group C than group M during first 24 hours which was statistically significant (p<0.05). The mean duration of total analgesia was significantly higher in group M. And total requirement of propofol and atracurium in control group were significantly higher compared to group receiving Mgso4.Conclusion: Perioperative use of magnesium sulphate as preloading and infusion shows reduced analgesic and anaesthetic drugs requirements in neck surgeries.