外用伊曲康唑纳米结构脂质载体凝胶治疗甲癣的研制

T. Kukreja, S. Saraf
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引用次数: 0

摘要

伊曲康唑是一种合成的三唑类抗真菌药物。伊曲康唑已被制成各种药理学制剂并以各种方式给药。伊曲康唑药片用于治疗可扩散到全身的肺部真菌感染。由于伊曲康唑尚未正式列入任何药典,因此仅公布了几种药物制剂的质量控制和稳定性测试程序。负载伊曲康唑的纳米结构脂质载体的研制。伊曲康唑NLC研制成功。根据我的调查,用于治疗甲癣的伊曲康唑外用NLC并不存在。稳定的伊曲康唑外用凝胶制剂的研制和评价是成功的。采用微乳液法制备伊曲康唑NLC,表明采用微乳液法制备伊曲康唑NLC是可行的。进一步,将ITZ- NLC加入胶凝剂中,并在特定参数下对其进行了评价。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Formulation of Topical Itraconazole Nanostructured Lipid Carriers (Nlc) Gel for Onychomycosis
Itraconazole is a triazole antifungal agent that is synthesised. Itraconazole has been manufactured into a variety of pharmacological formulations and administered by a variety of ways. Itraconazole pills are used to treat pulmonary fungal infections that can spread throughout the body. Because Itraconazole is not yet officially listed in any pharmacopoeia, only a few procedures for quality control and stability testing in pharmaceutical formulations have been published. The development of itraconazole-loaded nanostructured lipid carriers (ITZ-NLC). Itraconazole NLC have been successfully developed. Itraconazole topical NLC developed for the treatment of onychomycosis does not exist, according to my survey.The development and evaluation of stable itraconazole topical gel formulations proved successful. Itraconazole NLC was produced utilising the microemulsion method, indicating the viability of adopting this method as a continuous manufacturing tool for NLC formulation. Further, the ITZ- NLC was incorporated in the gelling agent and we evaluated it under specific parameters.
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