核糖激酶:原生动物化疗的可能靶点

Ogbunude Poj, Udeogaranya Po, A. Eze, Ikekpeazu Je, Okoli Ua
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引用次数: 1

摘要

抗寄生虫剂的开发具有很大的挑战性,特别是在利用寄生虫和宿主之间的生化差异时。然而,随着后基因组生物信息学和实验研究的发展,药物靶点可以更容易地识别。原生动物的核糖代谢引起了人们的兴趣,因为原生动物通常对嘌呤缺乏营养,并从宿主那里获得这些营养1。核糖被用于合成5-磷酸核糖所需的5-磷酸核糖,而5-磷酸核糖与嘌呤碱基一起用于合成核酸。负责将核糖转化为5-磷酸核糖的酶是核糖激酶(一种atp依赖的磷酸核糖激酶,EC 2.1.7.15)。在原生动物中,有四种可能的途径动员游离核碱基进行核酸合成,其中三种途径使用核糖激酶,一种途径使用转酮醇酶/转醛醇酶途径。抑制这些途径,即核糖激酶途径和转酮醇酶/转醛缩酶途径,将使寄生虫无法利用核碱基制造核酸。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ribokinase: A Possible Target for Chemotherapy of Protozoans
The development of anti-parasitic agent is quite challenging particularly when exploiting biochemical differences between the parasite and the host. However, with post-genome bioinformatics and experimental research, drug targets can be more easily identified. Ribose metabolism in protozoans is of interest because protozoa in general are auxotrophic for purines and acquire these nutrients from the hosts1. Ribose is utilized in the production of ribose 5-phosphate required for the synthesis of 5-phosphoribosyl-1-pyrophosphate that is used with purine bases for the synthesis of nucleic acids. The enzyme responsible for the conversion of ribose to ribose 5-phosphate is ribokinase (an ATP-dependent phosphoribosyl kinase, EC 2.1.7.15). Four possible pathways exist for mobilization of free nucleobases for the synthesis of nucleic acids in protozoans, three of these use ribokinase and one uses transketolase / transaldolase pathway. Inhibition of these pathways, that is, the ribokinase pathway and transketolase / transaldolase pathway will deny the parasites ability to use the nucleobases to make nucleic acids.
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