自噬在癌细胞中支持生存和促进死亡的双重对立作用:简要综述

Current Chemical Biology Pub Date : 2020-02-29 DOI:10.2174/2212796813666191111142824

E. El-Shafey, E. Elsherbiny

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引用次数: 7

摘要

自噬是细胞循环利用胞内物质以维持各种细胞功能稳态的良好过程。然而，自噬是一种在对抗条件下维持细胞存活的防御机制，自噬过程的诱导可能实质上导致细胞死亡。自噬的相互冲突的作用，包括允许细胞存活或促进细胞死亡，可能会对化疗药物的效率产生麻烦的影响。因此，了解自噬在癌症中的作用对于其在治疗中的最佳操作是至关重要的。

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Dual Opposed Survival-supporting and Death-promoting Roles of Autophagy in Cancer Cells: A Concise Review

Autophagy is a well-maintained process by which the cells recycle intracellular materials to maintain homeostasis in various cellular functions. However, autophagy is a defensive mechanism that maintains cell survival under antagonistic conditions, the induction of the autophagic process may substantially lead to cell death. The conflicting roles of autophagy including allowing cell survival or promoting cell death could have a troublesome impact on the efficiency of chemotherapeutic agents. Accordingly, understanding the role of autophagy in cancer is a vital need for its optimal manipulation in therapy.

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来源期刊

Current Chemical Biology Medicine-Biochemistry (medical)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Current Chemical Biology aims to publish full-length and mini reviews on exciting new developments at the chemistry-biology interface, covering topics relating to Chemical Synthesis, Science at Chemistry-Biology Interface and Chemical Mechanisms of Biological Systems. Current Chemical Biology covers the following areas: Chemical Synthesis (Syntheses of biologically important macromolecules including proteins, polypeptides, oligonucleotides, oligosaccharides etc.; Asymmetric synthesis; Combinatorial synthesis; Diversity-oriented synthesis; Template-directed synthesis; Biomimetic synthesis; Solid phase biomolecular synthesis; Synthesis of small biomolecules: amino acids, peptides, lipids, carbohydrates and nucleosides; and Natural product synthesis).