乙二胺钴(III)和钌(II)混合配体配合物的dna结合和光裂解研究

BioInorganic Reaction Mechanisms Pub Date : 2008-01-01 DOI:10.1515/IRM.2008.6.4.301

P. Nagababu, M. Shilpa, Md. B. Mustafa, P. Ramjee, S. Satyanarayana

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引用次数: 4

摘要

合成并表征了(en=乙二胺，pyip =(pyip = 2-(1-芘基)- 1h -咪唑[4,5-f][1,10]菲罗啉)，(aip = 2-(9-蒽基)- 1h -咪唑[4,5，-f][1,10]菲罗啉)。利用吸收(紫外/可见)和发射光谱、粘度测量以及DNA熔化和质粒DNA切割研究，研究了这些复合物与小牛胸腺DNA的相互作用。实验结果表明，这四种复合物都能以嵌入模式与DNA结合。复合物的dna结合亲和力

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DNA-binding and Photocleavage Studies of Ethylenediamine Cobalt(III) and Ruthenium(II) Mixed Ligand Complexes

,(en=ethylene-diamine, pyip =(pyip = 2-(1-pyrenyl)-1H-imidazo[4,5-f][1,10]phenanthroline),(aip = 2-(9-anthryl)-1H-imidazo[4,5,-f][1,10] phenanthroline) have been synthe-sized and characterized. The interaction of these complexes with calf thymus DNAwas investigated using absorption (UV/vis) and emission spectroscopy, viscositymeasurements as well as DNA melting and plasmid DNA cleavage studies. Theexperimental results show that the four complexes can bind to DNA in an intercala-tion mode. The DNA-binding afﬁnity of complex

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BioInorganic Reaction Mechanisms

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