血清胆红素水平预测急性冠脉综合征患者额叶QRS-T角变化

IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Güney Erdoğan, M. Yenerçağ, G. Durmuş, D. Koprulu, U. Arslan
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引用次数: 1

摘要

摘要:在急性冠脉综合征(ACS)患者中,血清胆红素水平对通过额叶QRS-T角变化表达的总缺血负荷改变的预测作用尚未研究。本研究旨在探讨ACS患者经皮冠状动脉介入治疗(PCI)后血清胆红素水平与额叶QRS-T角变化的关系。方法:根据基线额位QRS-T角度减去PCI术后额位QRS-T角度的值是否为正或负,将额位QRS-T角度变化视为正或负。将314例连续行PCI治疗的ACS患者根据QRS-T额叶角度变化阴性(n = 152)和QRS-T额叶角度变化阳性(n = 162)分为两组。结果:多因素logistic回归分析显示,c反应蛋白(CRP)与白蛋白比(CAR)(比值比[OR]: 0.519, 95% CI: 0.373 ~ 0.724, p <0.001)、总胆红素(OR: 3.687, 95% CI: 1.151 ~ 8.095, p = 0.03)、低密度脂蛋白(LDL) (OR: 0.985, 95% CI: 0.970 ~ 1.000, p = 0.04)是QRS-T角度变化阳性的独立预测因子。在受试者工作特征曲线分析中,总胆红素截断值0.59预测QRS-T角度阳性变化的敏感性为69%,特异性为65%(曲线下面积:0.739,p <0.001)。结论:在ACS患者中,血清总胆红素是一个有用的决策工具,可以预测QRS-T正位角变化,作为总缺血负担减轻的标志,独立于其他研究参数评估早期侵入策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum Bilirubin Level Predicts Frontal QRS-T Angle Change in Patients with Acute Coronary Syndrome
Abstract Introduction: The predictive role of serum bilirubin levels on the alteration of total ischemic burden expressed via frontal QRS-T angle change has never been studied in patients with acute coronary syndrome (ACS). In this study, we aimed to investigate the relationship between serum bilirubin levels and frontal QRS-T angle change after percutaneous coronary intervention (PCI) in ACS patients. Methods: Frontal QRS-T angle change was accepted as positive or negative according to whether the value of the baseline frontal QRS-T angle minus the post PCI frontal QRS-T angle is positive or negative. A total of 314 consecutive patients with ACS who underwent PCI were divided into two groups based on their negative frontal QRS-T angle change (n = 152 patients) and positive frontal QRS-T angle change (n = 162 patients). Results: Multivariate logistic regression analysis showed that the C-reactive protein (CRP) to albumin ratio (CAR) (Odds ratio [OR]: 0.519, 95% CI: 0.373–0.724, p <0.001), total bilirubin (OR: 3.687, 95% CI: 1.151–8.095, p = 0.03), and low-density lipoprotein (LDL) (OR: 0.985, 95% CI: 0.970–1.000, p = 0.04) were independent predictors of positive QRS-T angle change. In receiver operating characteristics curve analysis, a cut-off value of 0.59 total bilirubin had a 69% sensitivity and a 65% specificity (area under curve: 0.739, p <0.001) for the prediction of positive QRS-T angle change. Conclusion: In ACS patients, serum total bilirubin has been found to be a useful decision-making tool to predict positive frontal QRS-T angle change as a sign of reduced total ischemic burden, to assess early invasive strategy independently from other study parameters.
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