Myocardial infarction with nonobstructive coronary arteries: clinical characteristics and features of the acute period

The aim – to define the clinical and anamnestic features of myocardial infarction, which determine the prognosis of patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) in the acute period.Materials and methods. The study included 33 patients with MINOCA (group I), and 73 patients with myocardial infarction (MI) with obstructive coronary artery disease (CAD) (group II) who were hospitalized in Clinical hospital # 8. Angiography, echocardiography, ECG, clinical laboratory tests were performed for all patients.Results and discussion. As a result of a comparative analysis, it was found that the number of women in the group of patients with MINOCA (group I) was significantly higher than in group II (p=0.00001). The prevalence of risk factors such as hyperlipoproteinemia and smoking (p=0.0497; p=0.0096) in group I was lower than in group II. The average level of diastolic blood preasure in group I was significantly higher than in group II (p=0.002911). It was found that in the group I level of hemoglobin (p=0.003834), leukocytes (p=0.000376) and lymphocytes (p=0.003423) was significantly lower than in the group II, in group II diastolic dysfunction type I was prevailed (p=0.0084).Conclusions. Study showed that women were more likely to have MINOCA than men. Proportion of patients with hyperlipidemia and smoking in the group I was lower than in the group II. Patients in the group I more likely had diastolic dysfunction, lower hemoglobin and leukocytes level than in patient with MI with obstructive CAD. Independent factors associated with the development of complications in the acute period of MINOCA were a decrease in diastolic blood preasure, an increase in systolic blood preasure and age (multivariate regression logistic analysis).