玻璃体内抗vegf治疗急性视网膜色素上皮炎的疗效观察

中国实用眼科杂志 Pub Date : 2017-09-10 DOI:10.3760/CMA.J.ISSN.1006-4443.2017.09.018

Qingshan Chen, X. Xi, Fei Wang, Zhi Li

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引用次数: 0

摘要

目的评价抗vegf治疗急性视网膜色素上皮炎(ARPE)的疗效和安全性。方法对2013年10月~ 2015年2月收治的15例(15眼)ARPE患者进行病例对照研究。检查视力、眼底照片、FFA、OCT。将患者分为抗vegf组和对照组，随访2个月。结果两组患者BCVA基线值差异无统计学意义(P=0.06)。随访2个月后，治疗组BCVA明显高于对照组(P=0.001)。随访2个月，治疗组有8例IS/OS及RPE受损，对照组IS/OS及RPE受损未完全恢复。FFA也显示黄斑中心周围高荧光素。结论OCT和FFA证实ARPE的初始病变位于IS/OS和PRE内层之间。急性期视力下降与FFA的传递以及IS/OS和PRE内层的破坏有关。抗vegf治疗能快速改善ARPE患者的视力。关键词:视网膜色素上皮炎;抗vegf;之初

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The efficacy of intravitreal anti-VEGF therapy for acute retinal pigment epithelititis

Objective To evaluate efficacy and safety of anti-VEGF treatment for acute retinal pigment epitheliitis (ARPE) . Methods In this cases control study,15 cases (15eyes) of ARPE from October 2013 to February 2015 were studied. Vision acuity, fundus photographs, FFA and OCT were examined. The patients were divided into: anti-VEGF group and control group, and followed up 2 months. Results The difference in BCVA of two groups at baseline were not significant(P=0.06). BCVA of treatment group was significantly increased than that is the control group after 2 months followed up (P=0.001). Followed up 2 months, 8 cases in therapy group showed the impaired IS/OS and RPE layer were restored, however, the impaired IS/OS or RPE layer in control group were not completely restored. FFA also showed hyperfluorescein around macular center. Conclusion OCT and FFA repealed that initial lesion in ARPE located at the area between IS/OS and PRE inner layer. In acute stage, vision decreased associated with transmission of FFA, as well as disruption of IS/OS and PRE inner layer. Anti-VEGF therapy could improve visual acuity of ARPE quickly. Key words: Retinal pigment epitheliitis; anti-VEGF; Ranibizumab

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来源期刊

中国实用眼科杂志

自引率

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发文量

9101

期刊介绍： China Practical Ophthalmology was founded in May 1983. It is supervised by the National Health Commission of the People's Republic of China, sponsored by the Chinese Medical Association and China Medical University, and publicly distributed at home and abroad. It is a national-level excellent core academic journal of comprehensive ophthalmology and a series of journals of the Chinese Medical Association. China Practical Ophthalmology aims to guide and improve the theoretical level and actual clinical diagnosis and treatment ability of frontline ophthalmologists in my country. It is characterized by close integration with clinical practice, and timely publishes academic articles and scientific research results with high practical value to clinicians, so that readers can understand and use them, improve the theoretical level and diagnosis and treatment ability of ophthalmologists, help and support their innovative development, and is deeply welcomed and loved by ophthalmologists and readers.