反复流产母亲miR-146a生物标志物能力的评估

Parisa Ostadhasanzadeh, J. Mohseni, S. Ghorbian, Sedigheh Abdollahi fard, C. Ahmadizadeh
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引用次数: 0

摘要

背景。如果怀孕尝试失败,它可能会成为一个压力事件。因此,在许多情况下,解决问题可以使夫妻更满意和更团结,防止对家庭造成心理和社会伤害。本研究的目的是确定对照组和观察组产妇血液中miR-146a miRNA的表达是否存在显著差异,并确定该miRNA是否可以作为诊断性生物标志物。方法。本研究在数据分析方面是一个基础性的描述性调查。这些样本包括2019年9月至2021年2月期间到贾哈德大不里士大学就诊的孕妇。我们使用Exel, Spss v.21和Roc软件进行数据分析。数据在Exel软件中以参比基因和计算CT进行整理。在Roc软件中使用。结果。结果显示对照组和观察组之间存在差异。这些母亲应及早发现复发性流产。结论。通过使用所研究的mirna的诊断试剂盒,可以采取有效措施,早期发现,预防流产,减轻家庭沉重的心理、经济和社会负担。因此,建议针对这些生物标志物制作诊断试剂盒,并在不育中心使用。实际意义。在本研究的实际意义中,我们可以提到堕胎的诊断和预防,这可以减轻家庭和社会的负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of miR-146a biomarker capability in mothers with recurrent miscarriage
Background. If the pregnancy attempt fails, it may become a stressful event. Therefore, in many cases, problem solving can lead to greater satisfaction and cohesion of couples and prevent psychological and social harm to families. The aim of this study was to determine the significant difference in the expression of miR-146a miRNA in maternal blood between the control and observation groups and to determine whether the miRNA can be used as diagnostic biomarkers or not. Methods. The present study is a basic and descriptive survey in terms of data analysis. The samples included pregnant women referred to Tabriz University of Jahad from September 2019 to February 2021. We used Exel, Spss v.21 and Roc software for data analysis. Data were prepared in Exel software with reference gene and by calculating CT. Were used in Roc software. Results. The results showed a difference between the control and observation groups. Early detection of recurrent miscarriage should be used in these mothers. Conclusion. Through using diagnostic kits of the studied miRNAs, effective steps can be taken for early detection, prevention of abortion, and reducing the heavy psychological, economic, and social burden on families. Therefore, it is suggested that diagnostic kits be made for these biomarkers and used in infertility centers. Practical Implications. Among the practical implications of this study, we can mention the diagnosis and prevention of abortion, which can reduce the burden on families and society.
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