经颅直流电刺激和药物治疗在慢性疼痛患者疼痛管理中的效果

Atefeh Lotfi Jabali, Mina Mojtabaei, M. Mirhashemi
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摘要

背景:多种药物和非药物方法用于治疗慢性疼痛。经颅直流电刺激(tDCS)通过刺激中枢和周围神经是治疗慢性疼痛的一种不同的和有前途的方法。目的:本研究旨在探讨tDCS和药物治疗在伊朗德黑兰慢性疼痛患者疼痛管理中的有效性。方法:本研究采用临床试验设计。统计人群包括2020 - 21年间在德黑兰Pardis多学科疼痛诊所就诊的所有慢性疼痛患者。采用方便抽样的方法,共选择了60例愿意参与研究的患者。参与者被随机分为三组,包括药物治疗(加巴喷丁治疗,剂量为600 mg,每天两次),tDCS和对照组(每组n = 20)。研究工具包括麦吉尔疼痛问卷。采用SPSS软件(24.0版)进行重复测量方差分析。结果:结果显示,与对照组相比,药物治疗和tDCS干预均导致疼痛管理成分的平均得分降低(P < 0.001)。此外,两个实验组在疼痛管理成分上的效果没有显著差异。结论:tDCS和药物治疗对慢性疼痛患者的疼痛管理均有效。因此,除了药物治疗外,tDCS也被推荐用于慢性疼痛的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effectiveness of Transcranial Direct Current Stimulation and Pharmacotherapy in Pain Management in Patients with Chronic Pain
Background: A variety of pharmacological and nonpharmacological methods are used to treat chronic pain. Transcranial direct current stimulation (tDCS) through stimulating the central and peripheral nerves is a different and promising method for the treatment of chronic pain. Objectives: The present study aimed to investigate the effectiveness of tDCS and pharmacotherapy in pain management in patients with chronic pain in Tehran, Iran. Methods: The present study followed a clinical trial design. The statistical population comprised all patients with chronic pain who were referred to Pardis Multidisciplinary Pain Clinic in Tehran within 2020 - 21. A total of 60 patients willing to participate in the study were selected using convenience sampling. The participants were randomly divided into three groups, including pharmacotherapy (treatment by gabapentin with a dosage of 600 mg twice per day), tDCS, and control (n = 20 per group). The research instrument included the McGill Pain Questionnaire. The data were analyzed using repeated-measures analysis of variance with SPSS software (version 24.0). Results: The results showed that both pharmacotherapy and tDCS interventions led to a reduction in the mean scores of pain management components, compared to the control group (P < 0.001). Furthermore, there was no significant difference between the effects of the two experimental groups on pain management components. Conclusions: The tDCS and pharmacotherapy were both shown to be effective in pain management in patients with chronic pain. Therefore, in addition to pharmacotherapy, tDCS is also recommended for the treatment of chronic pain.
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