{"title":"用[18F]乙酰次萤石合成[18F]4-氟安替吡林的一种方便、高产率的方法","authors":"Mirko Diksic, Pasquale Diraddo","doi":"10.1016/0020-708X(85)90005-5","DOIUrl":null,"url":null,"abstract":"<div><p>This paper describes a convenient, high-yield synthesis of [<sup>18</sup>F]4-fluoroantipyrine, a blood flow tracer, by fluorination of antipyrine with [<sup>18</sup>F]acetylhypofluorite prepared <em>in situ</em>. The radiopharmaceutical was obtained in a radiochemical yield of 28 and 30% following HPLC and Sep-Pak purification, respectively. The two different purification procedures of the crude reaction are described. Sep-Pak filtration, after decomposition of the intermediary of the fluorination reaction by heating with NaOCH<sub>3</sub> in CH<sub>3</sub>CN, produced a radiopharmaceutical with radiochemical purity of more than 98%. The synthesis requires 50 min following irradiation.</p></div>","PeriodicalId":22517,"journal":{"name":"The International journal of applied radiation and isotopes","volume":"36 8","pages":"Pages 643-645"},"PeriodicalIF":0.0000,"publicationDate":"1985-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-708X(85)90005-5","citationCount":"8","resultStr":"{\"title\":\"A convenient, high-yield synthesis of [18F]4-fluoroantipyrine using [18F]acetylhypofluorite\",\"authors\":\"Mirko Diksic, Pasquale Diraddo\",\"doi\":\"10.1016/0020-708X(85)90005-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This paper describes a convenient, high-yield synthesis of [<sup>18</sup>F]4-fluoroantipyrine, a blood flow tracer, by fluorination of antipyrine with [<sup>18</sup>F]acetylhypofluorite prepared <em>in situ</em>. The radiopharmaceutical was obtained in a radiochemical yield of 28 and 30% following HPLC and Sep-Pak purification, respectively. The two different purification procedures of the crude reaction are described. Sep-Pak filtration, after decomposition of the intermediary of the fluorination reaction by heating with NaOCH<sub>3</sub> in CH<sub>3</sub>CN, produced a radiopharmaceutical with radiochemical purity of more than 98%. The synthesis requires 50 min following irradiation.</p></div>\",\"PeriodicalId\":22517,\"journal\":{\"name\":\"The International journal of applied radiation and isotopes\",\"volume\":\"36 8\",\"pages\":\"Pages 643-645\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1985-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0020-708X(85)90005-5\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The International journal of applied radiation and isotopes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0020708X85900055\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The International journal of applied radiation and isotopes","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0020708X85900055","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A convenient, high-yield synthesis of [18F]4-fluoroantipyrine using [18F]acetylhypofluorite
This paper describes a convenient, high-yield synthesis of [18F]4-fluoroantipyrine, a blood flow tracer, by fluorination of antipyrine with [18F]acetylhypofluorite prepared in situ. The radiopharmaceutical was obtained in a radiochemical yield of 28 and 30% following HPLC and Sep-Pak purification, respectively. The two different purification procedures of the crude reaction are described. Sep-Pak filtration, after decomposition of the intermediary of the fluorination reaction by heating with NaOCH3 in CH3CN, produced a radiopharmaceutical with radiochemical purity of more than 98%. The synthesis requires 50 min following irradiation.
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