Tiago M. Ribeiro de Oliveira , António J. Carmelo Romão , Pedro M. Simões de Oliveira , Sandro R. Silva Gaspar , Francisco M. Gamito Guerreiro , Tomé M. Matos Lopes
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引用次数: 1

摘要

目的放射引起的出血性膀胱炎是骨盆放射治疗的一个重要并发症,发病率和死亡率都很高。现有的保守治疗技术效果有限。高压氧已被证明是有效的治疗辐射引起的病变,包括放射性膀胱炎。我们的目的是分析高压氧治疗难治性放射性出血性膀胱炎的有效性和安全性。材料与方法回顾性分析我院收治的176例难治性放射性出血性膀胱炎患者的临床资料。肉眼血尿的变化是主要的治疗结果。结果23.9%的患者出现其他放射性软组织病变。平均37次高压氧治疗后,89.8%的患者血尿得到缓解。1.7%的患者报告了不良事件。结论高压氧治疗放射性出血性膀胱炎安全有效。伴随辐射引起的软组织病变相对频繁,这使得高压氧成为这些患者一线治疗的绝佳选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxigenoterapia hiperbárica na cistite rádica hemorrágica

Objective

Due to considerable morbidity and mortality rates, radiation‐induced hemorrhagic cystitis is an important complication of pelvic irradiation. The available conservative treatment techniques show limited results. Hyperbaric oxygen has shown to be effective in the treatment of radiation‐induced lesions, including radiation cystitis. Our aim was to analyze the effectiveness and safety of hyperbaric oxygen therapy for refractory radiation‐induced hemorrhagic cystitis.

Materials and Methods

Clinical records of 176 patients with refractory radiation‐induced hemorrhagic cystitis treated at our centre were retrospectively analyzed. The evolution of macroscopic hematuria was the main therapeutic outcome analyzed.

Results

23,9% of patients showed other radiation‐induced soft tissue lesions. After an average of 37 sessions of hyperbaric oxygen, 89,8% of patients showed resolution of hematuria. Adverse events were reported in 1,7% of patients.

Conclusions

Hyperbaric oxygen was a safe and effective therapy for radiation‐induced hemorrhagic cystitis. Concomitant radiation‐induced soft tissue lesions were relatively frequent, which makes hyperbaric oxygen an excellent choice as first line treatment in those patients.

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