同步辐射红外微光谱学:对生物医学的见解

IF 5.4 2区化学 Q1 INSTRUMENTS & INSTRUMENTATION

Applied Spectroscopy Reviews Pub Date : 2022-03-18 DOI:10.1080/05704928.2022.2052308

A. Refaat, G. Kamel

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引用次数: 2

摘要

人类健康是一个主题，需要从了解疾病的分子基础开始，发展诊断方法，然后找到可能的创新治疗方法。神经退行性疾病、退行性药物、糖尿病、先兆子痫和药剂学只是其中的几个例子。因此，科学界面临的挑战是开发新的和创造性的方法来获取、处理和解释与组织、单细胞或微环境中的细胞、细胞和亚细胞分辨率有关的生物分子信息。同步加速器设施为大量的生物和生物医学应用打开了大门，在这些应用中，高空间分辨率和高质量的信息是必不可少的。本文综述了同步辐射-傅里叶红外微光谱(SR-μFTIR)在生物医学各个领域的重要作用，并重点介绍了上述情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synchrotron radiation infrared microspectroscopy: Insights on biomedicine

Abstract Human health is a subject matter that requires a multifold strategy starting by understanding the molecular basis of diseases, development of diagnostic approaches, and subsequently by finding possible innovative treatments. Neurodegenerative diseases, degenerative medicine, diabetes, preeclampsia, and pharmaceutics are just a few examples to mention. Therefore, the challenge for the scientific community is to develop new and creative means for acquiring, processing and interpreting the biomolecular information involved with tissues, single cells or cells in a microenvironment, at cellular and sub-cellular resolution. Synchrotron facilities open the door for a huge number of biological and biomedical applications, where high spatial resolution and high quality information are a must. This review highlights the strong role that the Synchrotron radiation-FTIR microspectroscopy (SR-μFTIR) plays in various biomedical fields with a special focus on the above-mentioned cases.

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来源期刊

Applied Spectroscopy Reviews 工程技术-光谱学

CiteScore

13.80

自引率

1.60%

发文量

审稿时长

1 months

期刊介绍： Applied Spectroscopy Reviews provides the latest information on the principles, methods, and applications of all the diverse branches of spectroscopy, from X-ray, infrared, Raman, atomic absorption, and ESR to microwave, mass, NQR, NMR, and ICP. This international, single-source journal presents discussions that relate physical concepts to chemical applications for chemists, physicists, and other scientists using spectroscopic techniques.