血清肌钙蛋白I在脓毒症患者中的预后价值

Journal of the Bangladesh Society of Anaesthesiologists Pub Date : 2018-02-01 DOI:10.3329/jbsa.v31i1.66253

S. Reza, S. N. Jahan, Akm Ferdous Rahman, M. Asaduzzaman, Parvin Akhter, Rabeya Begum, Abdur Rahman

{"title":"血清肌钙蛋白I在脓毒症患者中的预后价值","authors":"S. Reza, S. N. Jahan, Akm Ferdous Rahman, M. Asaduzzaman, Parvin Akhter, Rabeya Begum, Abdur Rahman","doi":"10.3329/jbsa.v31i1.66253","DOIUrl":null,"url":null,"abstract":"Background: Sepsis is one of the leading causes of admission in ICU with high mortality and morbidity.Intensivists face challenges to manage sepsis in their practices particularly in a limited resource setting.The diagnosis of sepsis and its evaluation of severity are not easy because of its complex pathophysiologyand variable nature of presentation. So, researchers identified biomarkers including troponin I for potentialuse in sepsis. Of them troponin I is a useful biomarker with prognostic significance.\nMaterials and methods: This prospective observational study was conducted among purposively selected110 patients diagnosed as sepsis at intensive care unit (ICU) in Dhaka Medical College & Hospital. Afterfulfilling the inclusion and exclusion criteria, ECG was done to exclude MI. Then troponin I was measuredwith a cut of value of 0.6 ng/ml. the patients were followed up for a period upto 30 days. Statisticalassociations between categorical variables were tested using chi-square test and mean difference ofcontinuous variables by independent t-test. Correlation between troponin I value length of ICU stays andventilator days were calculated.\nResults:Among 110 patients diagnosed as sepsis 56.4% had normal troponin I and 43.6% had elevatedtroponin I. Distribution of elevated troponin I was higher among male patients (77.1% vs 64.5%) thanfemale. Mean duration of ICU stay was prolonged in elevated troponin I group as like ventilator support.Positive relationship was found between troponin level I and duration of ventilator support as well aslength of ICU stay (r=0.225, 0.279). There was significantly increased mortality rate in elevated troponingroup of patients compared to normal troponin group (72.9% vs 35.5%) in sepsis patients (p<0.001) followedby in severe sepsis 67.5% vs 35.48% (p=0.001) and 92.9% vs 57.1%) in septic shock (p<0.029).\nConclusion: This study showed that mortality and morbidity increases when troponin I value elevatedin sepsis.\nJBSA 2018; 31(1): 12-19","PeriodicalId":17242,"journal":{"name":"Journal of the Bangladesh Society of Anaesthesiologists","volume":"67 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prognostic Value of Serum Troponin I in Sepsis Patients\",\"authors\":\"S. Reza, S. N. Jahan, Akm Ferdous Rahman, M. Asaduzzaman, Parvin Akhter, Rabeya Begum, Abdur Rahman\",\"doi\":\"10.3329/jbsa.v31i1.66253\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Sepsis is one of the leading causes of admission in ICU with high mortality and morbidity.Intensivists face challenges to manage sepsis in their practices particularly in a limited resource setting.The diagnosis of sepsis and its evaluation of severity are not easy because of its complex pathophysiologyand variable nature of presentation. So, researchers identified biomarkers including troponin I for potentialuse in sepsis. Of them troponin I is a useful biomarker with prognostic significance.\\nMaterials and methods: This prospective observational study was conducted among purposively selected110 patients diagnosed as sepsis at intensive care unit (ICU) in Dhaka Medical College & Hospital. Afterfulfilling the inclusion and exclusion criteria, ECG was done to exclude MI. Then troponin I was measuredwith a cut of value of 0.6 ng/ml. the patients were followed up for a period upto 30 days. Statisticalassociations between categorical variables were tested using chi-square test and mean difference ofcontinuous variables by independent t-test. Correlation between troponin I value length of ICU stays andventilator days were calculated.\\nResults:Among 110 patients diagnosed as sepsis 56.4% had normal troponin I and 43.6% had elevatedtroponin I. Distribution of elevated troponin I was higher among male patients (77.1% vs 64.5%) thanfemale. Mean duration of ICU stay was prolonged in elevated troponin I group as like ventilator support.Positive relationship was found between troponin level I and duration of ventilator support as well aslength of ICU stay (r=0.225, 0.279). There was significantly increased mortality rate in elevated troponingroup of patients compared to normal troponin group (72.9% vs 35.5%) in sepsis patients (p<0.001) followedby in severe sepsis 67.5% vs 35.48% (p=0.001) and 92.9% vs 57.1%) in septic shock (p<0.029).\\nConclusion: This study showed that mortality and morbidity increases when troponin I value elevatedin sepsis.\\nJBSA 2018; 31(1): 12-19\",\"PeriodicalId\":17242,\"journal\":{\"name\":\"Journal of the Bangladesh Society of Anaesthesiologists\",\"volume\":\"67 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Bangladesh Society of Anaesthesiologists\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3329/jbsa.v31i1.66253\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Bangladesh Society of Anaesthesiologists","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/jbsa.v31i1.66253","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

背景:脓毒症是ICU住院的主要原因之一，具有很高的死亡率和发病率。重症医师面临着管理败血症的挑战，特别是在资源有限的情况下。脓毒症的诊断和严重程度的评估是不容易的，因为其复杂的病理生理和变化的性质表现。因此，研究人员确定了包括肌钙蛋白I在内的生物标志物，可能用于败血症。其中肌钙蛋白I是一种有用的具有预后意义的生物标志物。材料和方法:本前瞻性观察研究在达卡医学院医院重症监护病房(ICU)有目的选择110例败血症患者进行。在满足纳入和排除标准后，进行心电图检查以排除心肌梗死。然后测量肌钙蛋白I，切值为0.6 ng/ml。对患者进行为期30天的随访。分类变量间的统计相关性采用卡方检验，连续变量间的均差采用独立t检验。计算肌钙蛋白I值与ICU住院时间与呼吸机天数的相关性。结果:在110例败血症患者中，56.4%的患者肌钙蛋白I正常，43.6%的患者肌钙蛋白I升高。男性患者肌钙蛋白I升高(77.1%比64.5%)高于女性。肌钙蛋白I升高组与呼吸机支持组相比，平均住院时间延长。肌钙蛋白I水平与呼吸机支持时间和ICU住院时间呈正相关(r=0.225, 0.279)。在脓毒症患者中，肌钙蛋白升高组的死亡率明显高于正常肌钙蛋白组(72.9% vs 35.5%) (p<0.001)，严重脓毒症患者的死亡率分别为67.5% vs 35.48% (p=0.001)和92.9% vs 57.1% (p<0.029)。结论:本研究表明，当肌钙蛋白I值升高时，脓毒症的死亡率和发病率增加。JBSA 2018;31 (1): 19

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Prognostic Value of Serum Troponin I in Sepsis Patients

Background: Sepsis is one of the leading causes of admission in ICU with high mortality and morbidity.Intensivists face challenges to manage sepsis in their practices particularly in a limited resource setting.The diagnosis of sepsis and its evaluation of severity are not easy because of its complex pathophysiologyand variable nature of presentation. So, researchers identified biomarkers including troponin I for potentialuse in sepsis. Of them troponin I is a useful biomarker with prognostic significance. Materials and methods: This prospective observational study was conducted among purposively selected110 patients diagnosed as sepsis at intensive care unit (ICU) in Dhaka Medical College & Hospital. Afterfulfilling the inclusion and exclusion criteria, ECG was done to exclude MI. Then troponin I was measuredwith a cut of value of 0.6 ng/ml. the patients were followed up for a period upto 30 days. Statisticalassociations between categorical variables were tested using chi-square test and mean difference ofcontinuous variables by independent t-test. Correlation between troponin I value length of ICU stays andventilator days were calculated. Results:Among 110 patients diagnosed as sepsis 56.4% had normal troponin I and 43.6% had elevatedtroponin I. Distribution of elevated troponin I was higher among male patients (77.1% vs 64.5%) thanfemale. Mean duration of ICU stay was prolonged in elevated troponin I group as like ventilator support.Positive relationship was found between troponin level I and duration of ventilator support as well aslength of ICU stay (r=0.225, 0.279). There was significantly increased mortality rate in elevated troponingroup of patients compared to normal troponin group (72.9% vs 35.5%) in sepsis patients (p<0.001) followedby in severe sepsis 67.5% vs 35.48% (p=0.001) and 92.9% vs 57.1%) in septic shock (p<0.029). Conclusion: This study showed that mortality and morbidity increases when troponin I value elevatedin sepsis. JBSA 2018; 31(1): 12-19

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of the Bangladesh Society of Anaesthesiologists

自引率

0.00%

发文量