可溶性ST2在心血管疾病的诊断、排除和治疗监测方面具有广阔的应用前景

Q4 Health Professions

中华检验医学杂志 Pub Date : 2020-03-11 DOI:10.3760/CMA.J.ISSN.1009-9158.2020.03.009

Liying Song, Hui Yuan

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引用次数: 0

摘要

可溶性ST2(Soluble ST2, sST2)是白细胞介素-33 (interleukin-33, IL-33)的诱骗受体，与后者结合而不进行下游调控。IL-33/ST2轴调节多个系统，减轻或加重疾病。循环sST2可在一定程度上反映炎症反应。sST2可用于预后监测、疗效监测和危险分层。本文总结了近年来sST2在临床试验中的研究进展，并对sST2检测的未来发展方向进行了展望。为sST2在患者管理和治疗决策中的广泛应用，检验医学从业者和医生应该做出更多的努力和贡献。关键词:白细胞介素;生物标志物;心力衰竭;预后

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Soluble ST2 is promising in the diagnosis of cardiovascular disease exclusion and therapy monitoring

Soluble ST2(sST2) is a decoy receptor of interleukin-33 (IL-33), which binds to the later without exerting downstream regulation. The IL-33/ST2 axis regulates several systems, relieve or aggravate the diseases. Circulating sST2 can reflect the inflammatory response to a certain extent. sST2 can be used in prognosis, monitory curative monitory and risk stratification. Here we summarize recent researches of sST2 in clinical trials and progress and highlight the future direction of the sST2 detection. More efforts and contributions should be made by laboratory medicine practitioners and doctors for widely use of sST2 in patient management and treatment decisions. Key words: Interleukin; Biomarkers; Heart Failure; Prognosis

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来源期刊

中华检验医学杂志 Health Professions-Medical Laboratory Technology

CiteScore

0.40

自引率

0.00%

发文量

8037

期刊介绍：