{"title":"青少年组蛋白H3.3 G34突变的高级别胶质瘤的临床病理和遗传学特征","authors":"Yuanyuan Cheng","doi":"10.33696/PATHOLOGY.1.006","DOIUrl":null,"url":null,"abstract":"33 Chromatin is composed of nucleosomes, with each nucleosome consisting of an octamer of two copies each of histones H3, H4, H2A, and H2B. Chromatin is critical for the control of transcription, replication, DNA repair and other aspects of genomic stability. In humans, there are different histone H3 variants. H3.3 proteins are expressed thoughout the cell cycle as well as in quiescent cells [1], while H3.1 and H3.2 are expressed only during the S-phase [2].","PeriodicalId":12291,"journal":{"name":"Experimental pathology","volume":"29 4 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Clinicopathological and Genetic Characteristics of High-grade Gliomas with Histone H3.3 G34 Mutation in Teenagers and Young adults\",\"authors\":\"Yuanyuan Cheng\",\"doi\":\"10.33696/PATHOLOGY.1.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"33 Chromatin is composed of nucleosomes, with each nucleosome consisting of an octamer of two copies each of histones H3, H4, H2A, and H2B. Chromatin is critical for the control of transcription, replication, DNA repair and other aspects of genomic stability. In humans, there are different histone H3 variants. H3.3 proteins are expressed thoughout the cell cycle as well as in quiescent cells [1], while H3.1 and H3.2 are expressed only during the S-phase [2].\",\"PeriodicalId\":12291,\"journal\":{\"name\":\"Experimental pathology\",\"volume\":\"29 4 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33696/PATHOLOGY.1.006\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33696/PATHOLOGY.1.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Clinicopathological and Genetic Characteristics of High-grade Gliomas with Histone H3.3 G34 Mutation in Teenagers and Young adults
33 Chromatin is composed of nucleosomes, with each nucleosome consisting of an octamer of two copies each of histones H3, H4, H2A, and H2B. Chromatin is critical for the control of transcription, replication, DNA repair and other aspects of genomic stability. In humans, there are different histone H3 variants. H3.3 proteins are expressed thoughout the cell cycle as well as in quiescent cells [1], while H3.1 and H3.2 are expressed only during the S-phase [2].
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