D. E. Grocock, T. K. Jones, G. Hallas, J. Hepworth
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引用次数: 10
摘要
1,3-双三氟甲基苯与正丁基锂- nnn ' n ' -四亚甲基乙二胺配合物的金属化基本上只发生在2位上，而与正丁基锂单独发生金属化则会产生混合物。正丁基锂主要在4位与n-二甲基-3,5-双三氟甲基苯胺反应。用溴水溶液处理3,5-双三氟甲基苯胺得到二溴化合物。根据1H核磁共振数据分配结构。
Metallation of 1,3-bistrifluoromethylbenzene and NN-dimethyl-3,5-bistrifluoromethylaniline
The metallation of 1,3-bistrifluoromethylbenzene with the n-butyl-lithium–NNN′N′-tetramethylethylenediamine complex occurs essentially only at the 2-position, but with n-butyl-lithium alone a mixture of products results. n-Butyl-lithium reacts with NN-dimethyl-3,5-bistrifluoromethylaniline mainly at the 4-position. Treatment of 3,5-bistrifluoromethylaniline with aqueous bromine gives a dibromo-compound. Structures are assigned on the basis of 1H n.m.r. data.
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