{"title":"毒理学剂量x时间=物理常数范式的基础","authors":"K. Rozman","doi":"10.2174/1874143600802010087","DOIUrl":null,"url":null,"abstract":"The relationship dose x time = constant (mg · hr) has been reported in many toxicological experiments during the past 100 years. It was handled as a curiosity until Rozman and Doull pointed out that it can be found in every experi- ment that is conducted under equilibrium conditions which is called steady state in pharmacology and toxicology. This manuscript suggests that this relationship is consistent with the most basic laws of physics.","PeriodicalId":22907,"journal":{"name":"The Open Pharmacology Journal","volume":"19 1","pages":"87-88"},"PeriodicalIF":0.0000,"publicationDate":"2008-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"The Foundation of Toxicology’s Dose x Time = Constant Paradigm in Physics\",\"authors\":\"K. Rozman\",\"doi\":\"10.2174/1874143600802010087\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The relationship dose x time = constant (mg · hr) has been reported in many toxicological experiments during the past 100 years. It was handled as a curiosity until Rozman and Doull pointed out that it can be found in every experi- ment that is conducted under equilibrium conditions which is called steady state in pharmacology and toxicology. This manuscript suggests that this relationship is consistent with the most basic laws of physics.\",\"PeriodicalId\":22907,\"journal\":{\"name\":\"The Open Pharmacology Journal\",\"volume\":\"19 1\",\"pages\":\"87-88\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-08-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Pharmacology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874143600802010087\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Pharmacology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874143600802010087","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Foundation of Toxicology’s Dose x Time = Constant Paradigm in Physics
The relationship dose x time = constant (mg · hr) has been reported in many toxicological experiments during the past 100 years. It was handled as a curiosity until Rozman and Doull pointed out that it can be found in every experi- ment that is conducted under equilibrium conditions which is called steady state in pharmacology and toxicology. This manuscript suggests that this relationship is consistent with the most basic laws of physics.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
