Similarity and difference of organizations of streptomycetic landomycins clusters

Aim. The aim of the work is to establish the level of similarity of the primary structure and organization of landomycin clusters of streptomycetes. Methods. Information on nucleotide sequences and annotations of streptomycetic clusters of landomycin biosynthesis genes AF080235,1, KJ645792.1, HQ828984.1 and genomes of strains S. cyanogenus S136, S. globisporus 1912-4Crt is freely available in GenBank. Analysis of the nucleotide sequences of streptomycetes was performed using the program BLASTN from the server NSBI. Results. The remote localization of a number of probable lan-cluster genes (prx, lanW, lanYR) has been established. The sequences of similar lndU / lanU genes and lndY / lanY genes, which are not necessary for landomycin biosynthesis, have been shown to be the least similar. It is shown that the lan-cluster of S. cyanogenus S136 is expected to be localized outside the cortical region of the chromosome of the strain. Landomycin-producing streptomycetes are isolated from soil samples from different ecological niches on different continents of the planet. Conclusions. The difference in the organization of lan- and lnd-clusters is expressed in the remote localization of a number of genes (prx, lanW, lanYR).