碳和金离子注入表面对神经元StemCellsâÂÂ功能的影响

Emel Sokullu, Taner DaÄcÄ, O. Gözen, Fulya Ersoy, A. Oztarhan
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引用次数: 0

摘要

几十年来,生物材料一直用于医学,以改善组织和器官的功能。它们也被用作假体和植入物,用来代替缺少的器官或组织的功能。碳(C)和金(Au)由于其生物相容性而被特别选择,并作为植入物应用了几十年。碳和金也是医学应用的重要离子来源。本研究通过离子注入技术对聚苯乙烯盘子进行了金离子和碳离子的改性。利用这种表面修饰方法,旨在改善神经干细胞的表面特性,获得具有生物活性的表面。尽管干细胞的整合很有希望,但神经干细胞的研究仍有许多里程碑要达到。神经再生是神经系统疾病患者最期望的功能。改变支架的表面特性是促进再生的一种途径,离子注入是改变支架表面特性的方法之一,对促进细胞的增殖和整合起着巨大的作用。在本研究中,我们观察到离子注入刺激了神经细胞的增殖,而在细胞培养表面注入不同的离子是详细确定该技术对细胞粘附、增殖、分化和凋亡特性影响的必要条件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effects of Carbon and Gold Ion Implanted Surfaces on Neuronal StemCellsâ Functions
Biomaterials have been used in medicine for decades to improve the functions of tissues and organs. They are also used as prosthesis and implants which are designed to substitute functions of a lacking organ or tissue. Carbon (C) and Gold (Au) were particularly chosen due to their biocompatibility and applied as implants for decades. Carbon and gold were great ion sources for medical applications, as well. In this study, polystyrene dishes were modified using gold and carbon ions via ion implantation technique. Using this surface modification method, it was aimed to improve surface characteristics and achieve a bioactive surface for neural stem cells. Even though the integration of stem cells was promising, neural stem cell studies still have many milestones to reach. Neuro-regeneration was the most desired function for people who suffer from neural system diseases. Changing surface characteristics of scaffolds was a way to promote regeneration and ion implantation was one of the methods to modify surface properties which play a huge role in enhancing the proliferation and integration of cells. In this study, it was observed that the ion implantation stimulated the neural proliferation and the implantation of different ions on cell culture surfaces was essential to determine the effects of this technique on adhesion, proliferation, differentiation and apoptosis properties of cells in details.
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