Chenyang Lei, Juan Jiang, Yanyan Zhang, Gaoyun Xiong
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Role and Function of Regulatory T Cell in Chronic Rhinosinusitis with Nasal Polyposis.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis characterized by high edema in the stroma, albumin deposition, and formation of pseudocysts. The pathogenesis of CRSwNP is not yet fully understood. Regulatory T (Treg) cells are a subset of CD4+ T cells that play a suppressive immunoregulatory role in the process of CRSwNP. Recent studies have found that there was a significant reduction in Treg cells in polyp tissues, which leads to the onset of CRSwNP. An imbalance between Th17 and Treg cells can also aggravate inflammation toward the Th2 type. This review focuses on our understanding of the function and role of Treg cells and their regulatory factors and clinical significance in CRSwNP. We also summarize the current drug treatments for CRSwNP with Tregs as the potential therapeutic target, which will provide new ideas for the treatment of CRSwNP in the future.
期刊介绍：
Natural Language & Linguistic Theory provides a forum for the discussion of theoretical research that pays close attention to natural language data, offering a channel of communication between researchers of a variety of points of view. The journal actively seeks to bridge the gap between descriptive work and work of a highly theoretical, less empirically oriented nature. In attempting to strike this balance, the journal presents work that makes complex language data accessible to those unfamiliar with the language area being studied and work that makes complex theoretical positions more accessible to those working outside the theoretical framework under review. Natural Language & Linguistic Theory features: generative studies on the syntax, semantics, phonology, morphology, and other aspects of natural language; surveys of recent theoretical developments that facilitate accessibility for a graduate student readership; reactions/replies to recent papers book reviews of important linguistics titles; special topic issues. Springer fully understands that access to your work is important to you and to the sponsors of your research. We are listed as a green publisher in the SHERPA/RoMEO database, as we allow self-archiving, but most importantly we are fully transparent about your rights. Read more about author''s rights on: http://www.springer.com/gp/open-access/authors-rights
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