唐氏综合征脑组织谷氨酸受体基因的时空差异表达

A. Ortiz, Mailyn Alejandra Bedoya Saldarriaga, Julio César Montoya Villegas, F. García-Vallejo
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引用次数: 0

摘要

研究谷氨酸受体的表达失调对于更好地理解唐氏综合征(DS)患者认知障碍的相关机制至关重要。利用GEO数据集的微阵列实验数据,我们研究了26个谷氨酸受体基因在DS脑样本中从产前到成年的几种脑结构中的表达。总的来说,我们的结果显示了基因表达的复杂性,这些基因主要取决于所分析的大脑结构;特别是海马体表现出不同的表达模式。在一般的大脑分析中,过表达的基因是GRIN3A和GRIN2C,而在海马中,GRM1、GRID2和GRIK1基因受体的表达水平较高。我们的研究结果表明,人类大脑中与其他神经递质系统相关的谷氨酸能系统可能与谷氨酸能受体的改变相关,从而导致DS模型的突触改变和认知缺陷。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Temporal and Spatial Differential Expression of Glutamate Receptor Genes in the Brain of Down Syndrome
Studying the dysregulation of expression of glutamate receptors is crucial to better understand the mechanisms associated with cognitive disabilities in Down syndrome (DS) patients. By using data of microarray experiments previously deposited in GEO Dataset, we studied the expression of 26 glutamate receptor genes in DS brain samples since prenatal to adult age in several brain structures. Overall, our results showed a complexity in the expression of the genes which were depen-dent mainly on the brain structure analyzed; especially, the hippocampus showed a different expression pattern. While in the general brain analysis the overexpressed genes were GRIN3A and GRIN2C, higher expression levels of GRM1, GRID2, and GRIK1 gene receptors were recorded in hippocampus. Our results suggest that the glutamatergic system in association with other neurotransmitter systems in the human brain would associate with glutamatergic receptor alterations to bring upon synaptic changes and cognitive deficits in DS models.
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