{"title":"表观遗传修饰、表观遗传生物标志物和膳食补充剂在神经退行性疾病中的作用","authors":"Faiza Naseer","doi":"10.35248/2375-4273.19.07.242","DOIUrl":null,"url":null,"abstract":"Neurodegenerative diseases are outcome of epigenetic modification and environmental factors. With the age, due to epimutation neural cell get harm and affect the cognitive function. Epigenetic biomarkers such as DNA methylation, histone modification and miRNA alter the genes functions, involved in many cellular processes. Early detection of these biomarkers help in early diagnosis of diseases. In this article we have focus on how epigenetic alteration affects the expression of genes and epigenetic biomarkers help in earlier diagnosis. We also have focus on dietary supplements which help in slowing the progression of disease.","PeriodicalId":91261,"journal":{"name":"Health care. Current reviews","volume":"18 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of Epigenetic Modification, Epigenetic Biomarkers and Dietary Supplements in Neurodegenerative Diseases\",\"authors\":\"Faiza Naseer\",\"doi\":\"10.35248/2375-4273.19.07.242\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Neurodegenerative diseases are outcome of epigenetic modification and environmental factors. With the age, due to epimutation neural cell get harm and affect the cognitive function. Epigenetic biomarkers such as DNA methylation, histone modification and miRNA alter the genes functions, involved in many cellular processes. Early detection of these biomarkers help in early diagnosis of diseases. In this article we have focus on how epigenetic alteration affects the expression of genes and epigenetic biomarkers help in earlier diagnosis. We also have focus on dietary supplements which help in slowing the progression of disease.\",\"PeriodicalId\":91261,\"journal\":{\"name\":\"Health care. Current reviews\",\"volume\":\"18 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Health care. Current reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35248/2375-4273.19.07.242\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health care. Current reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35248/2375-4273.19.07.242","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Role of Epigenetic Modification, Epigenetic Biomarkers and Dietary Supplements in Neurodegenerative Diseases
Neurodegenerative diseases are outcome of epigenetic modification and environmental factors. With the age, due to epimutation neural cell get harm and affect the cognitive function. Epigenetic biomarkers such as DNA methylation, histone modification and miRNA alter the genes functions, involved in many cellular processes. Early detection of these biomarkers help in early diagnosis of diseases. In this article we have focus on how epigenetic alteration affects the expression of genes and epigenetic biomarkers help in earlier diagnosis. We also have focus on dietary supplements which help in slowing the progression of disease.
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