p21活化激酶1和2作为心血管疾病管理的潜在治疗靶点

Honglin Xu, Dingwei Wang, Chiara Ramponi, X. Wang, Hongyuan Zhang
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引用次数: 2

摘要

p21活化激酶1和2作为心血管疾病管理的潜在治疗靶点徐洪林,王定伟,Chiara Ramponi,王鑫,张宏远*,Michael Smith building,曼彻斯特大学生物、医学与健康学院心血管科学系,曼彻斯特,英国*通讯:hongyuan.zhang-3@postgrad.manchester.ac.uk收稿日期:2022年10月20日接收日期:2022年11月16日发布日期:2022年12月21日摘要:I组p21活化激酶(Paks)是丝氨酸/苏氨酸蛋白激酶家族的成员。Paks由三个基因(pak1 - 3)编码,参与多种生物过程的调控。Pak1和Pak2是关键成员,在其激酶结构域中具有91%的序列同一性。最近的研究表明,Pak1/2可以保护心脏免受各种压力的影响。活化的Pak1/2参与维持细胞内稳态和代谢,从而增强心肌细胞对应激的适应和恢复能力。现就Pak1/2的结构、激活、功能及其对心血管疾病发生的保护作用作一综述。本文还讨论了Pak1/2作为治疗靶点的价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The P21-Activated Kinase 1 and 2 As Potential Therapeutic Targets for the Management of Cardiovascular Disease
Review The P21-Activated Kinase 1 and 2 As Potential Therapeutic Targets for the Management of Cardiovascular Disease Honglin Xu, Dingwei Wang, Chiara Ramponi, Xin Wang, and Hongyuan Zhang * Michael Smith building, Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. * Correspondence: hongyuan.zhang-3@postgrad.manchester.ac.uk     Received: 20 October 2022 Accepted: 16 November 2022 Published: 21 December 2022   Abstract: Group I p21-activated kinases (Paks) are members of the serine/threonine protein kinase family. Paks are encoded by three genes (Pak 1‒3) and are involved in the regulation of various biological processes. Pak1 and Pak2 are key members, sharing 91% sequence identity in their kinase domains. Recent studies have shown that Pak1/2 protect the heart from various types of stresses. Activated Pak1/2 participate in the maintenance of cellular homeostasis and metabolism, thus enhancing the adaptation and resilience of cardiomyocytes to stress. The structure, activation and function of Pak1/2 as well as their protective roles against the occurrence of cardiovascular disease are described in this review. The values of Pak1/2 as therapeutic targets are also discussed.
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