Generating the Responses Immune with Honey, Saussurea costus, and Nigella Sativa in Cellular and Humoral May Resolve COVID-19?

Backgrounds: Covid-19 has become pandemic in the world, including Indonesia. Some Indonesia Covid-19 people tried to consume Honey, Sausseria coctus, and Nigella sativa for curing the Covid-19 disease. From many testimonies, citizen Indonesia people with no need to take hospitalization have reported a cure if they consumed it. Aims: To make evidence-based medicine that Honey, Sausseria coctus dan Nigella may cure the Covid-19 Methods: We used to post only control design and mice as an animal model. The research divided mice into two groups, and the first group as control received PBS as a placebo. Then the second group, we gave Honey, Sausseria coctus dan Nigella sativa. All of the regiment enters the mouth with special sonde to reach the gastrointestinal organ. After administration regiments a long three weeks, we sacrificed the mice. We evaluated cellular immune responses that are Th2, Th17, and NK cells. We check for humoral immune response, TGF-β, IL-17A, sIgA, IL-4, IL-4, B-def, and IgG. Results: We got deference Th2 and Th17 between control with treatment group (p=0.05). For markers, humoral immunity all has deference between control with treatment group (p=>0.05) statistically, but one (IL-17A) have no statistical difference. Conclusions: We want to continue studying immune responses in humans with COVID-19 if giving Honey, Sausseria coctus, and Nigella sativa.