DANIO RERIO AS A MODEL FOR STUDYING REPRODUCTIVE RISKS ASSOCIATED WITH HUMAN EXPOSURE TO POLYCHLORINATED BIPHENILS. A SYSTEMATIC REVIEW.

This systematic review is the result of a search, critical analysis and synthesis of qualitative evidence of adverse effects on reproductive function, postembryonic survival and morphofunctional development of offspring in aquarium fish Danio rerio (Zebrafish), which are widely used in experimental studies to model carcinogenic, mutagenic and general toxic effects when human are exposed to a large class of persistent organic pollutants, including polychlorinated biphenyls (PCBs). The literature search was carried out in the international scientific databases Web of Science, Scopus, PubMed, and eLibrary in accordance with the PRISMA 2020 recommendations. A total of 613 articles were identified, of which 14 articles were selected for detailed analysis. In 11 publications, the assessment of PCB exposure-related impact on the reproductive system of Danio rerio was presented, and in 8 articles reported on the results of studying the effect of parental exposure to PCBs on the offspring viability and its postembryonic development. It is noted that the adverse effects of PCBs, or their mixtures with other POPs, on the reproductive system of Danio rerio males have been studied to a much lesser extent than in females. The risk transmission of morphological and functional disorders to subsequent generations associated with separate parental exposure to PCBs of both sexes, and the dose-response relationship, judging by the published works, have not received a proper assessment. The developmental disorders in offspring were studied only for the first generation after parental exposure to mixtures of POPs and PCBs. The lack of such information does not allow for a correct assessment of the transgenerational risk inheritance phenomenon of morphological and functional disorders associated with the progenitors exposure to PCBs and other environmental endocrine-disrupting pollutants. The results of the performed analysis can be useful in planning an experimental quantitative assessment, predicting and preventing human reproductive health impairments and the health of future generations.