抗氧化剂如何影响清道夫受体的作用

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引用次数: 0

摘要

与过去相比,今天的生活方式发生了变化。食用垃圾食品和不健康食品会增加心脏病发作的风险。动脉粥样硬化是一种由多种因素引起的炎症性疾病,可导致心血管疾病。巨噬细胞、内皮细胞、OX-LDL和一些氧化剂如活性氧(ROS)是这种转化的原因,它们在引起心血管疾病中起重要作用。高脂血症是动脉粥样硬化的主要原因。多吃高脂肪食物和快餐会增加患动脉粥样硬化的风险。巨噬细胞是源自单核细胞的特殊细胞,可以形成斑块,从而增加动脉粥样硬化的风险。姜黄素是一种重要的抗炎症物质,可以降低心血管疾病的风险。一些研究表明,一类SRs, SR-AI和SR-AII,以及B类的2个成员,CD36和SR-BI参与了动脉粥样硬化的过程。一些研究强烈表明口服抗氧化剂对动脉粥样硬化的治疗是有效的,但除普罗布考外,大多数研究都不成功。本研究的目的是阐明姜黄素作为抗氧化剂对动脉粥样硬化过程和清道夫受体激活的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
How Antioxidant Have an Effect on Scavenger Receptors Action
Today’s lifestyle has changed in comparison with the past. Using junk foods and unhealthy foods leads to increasing the risk of heart attacks. Atherosclerosis is an inflammation disease made by many factors that lead to cardiovascular diseases (CVD). Macrophages, endothelial cells, OX-LDL, and some oxidants such as reactive oxygen species (ROS) are the reasons for this transformation, and they have an important role in causing cardiovascular disease. Hyperlipidemia is a major reason for atherosclerosis. Increase in the use of fatty food and fast food can lead to a rise in the risk of atherosclerosis. Macrophages are special cells derived from monocytes and can make plaque which led to increased risk of atherosclerosis. Curcumin is one of important ant inflammation can reduce the risk of CVD. Some studies illustrate that a class SRs, SR-AI and SR-AII, and 2 members of the B class, CD36 and SR-BI, involved in atherosclerosis process. Some studies strongly suggest that oral antioxidants are effective in atherosclerosis treatment, most of them have been unsuccessful except probucol. The aim of this study is illustrating that how curcumin as antioxidant can effect on atherosclerosis proses and scavenger receptor’s activation.
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