明胶-羧甲基壳聚糖水凝胶的溶胀、粘弹性、电学和药物释放特性研究

Q2 Materials Science
P. Pandey, I. Banerjee, A. Anis, K. Pal
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引用次数: 5

摘要

摘要本研究对明胶-羧甲基壳聚糖水凝胶进行了深入分析。复合体系形成相分离的水凝胶,扫描电镜证实了这一点。羧甲基壳聚糖水凝胶的溶胀率低于明胶水凝胶。采用静态力学试验机进行的宏观变形研究表明,水凝胶具有粘弹性。随着羧甲基壳聚糖含量的增加,水凝胶的阻抗降低。水凝胶的药物释放以菲克扩散为主,以活性形式释放。结果提示水凝胶作为药物递送基质的潜在应用前景。图形抽象
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Insight on the Swelling, Viscoelastic, Electrical, and Drug Release Properties of Gelatin–Carboxymethyl Chitosan Hydrogels
ABSTRACT The present study reports the in-depth analysis of the gelatin–carboxymethyl chitosan hydrogels. The composite system formed phase-separated hydrogels, which is confirmed by scanning electron microscopy. The swelling of the carboxymethyl chitosan-containing hydrogels was lower than the gelatin hydrogel. Macroscale deformation study using a static mechanical tester indicated a viscoelastic nature of the hydrogels. A decrease in the impedance of the hydrogels was observed with an increase in the carboxymethyl chitosan content. The drug release from the hydrogels was predominantly Fickian diffusion mediated and was released in its active form. The results suggested the potential use of the hydrogels as drug delivery matrices. GRAPHICAL ABSTRACT
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来源期刊
Polymer-Plastics Technology and Engineering
Polymer-Plastics Technology and Engineering 工程技术-高分子科学
CiteScore
1.71
自引率
0.00%
发文量
0
审稿时长
4 months
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