路易体痴呆患者的预期寿命:多奈哌齐和特殊养老院替代的影响。田尻工程的回顾分析

K. Meguro, Keiichi Kumai, J. Takada, Keiko Chida, Yuriko Kato, S. Yamaguchi
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引用次数: 3

摘要

目的:胆碱酯酶抑制剂(ChEIs)可延缓阿尔茨海默病(AD)的进展。我们之前证明了多奈哌齐(DNP)治疗和特殊疗养院(SNH)替代对阿尔茨海默病发病后预期寿命的积极影响。最近,DNP已被用于治疗路易体痴呆(DLB);然而,对预期寿命的影响尚不清楚。本文分析了DNP对DLB的影响。方法:回顾性分析1999- 2012年在Tajiri诊所就诊并有医疗记录和死亡证明的所有患者。入选标准是基于DSM-IV标准的痴呆诊断和使用国际共识标准的DLB诊断;治疗3个月以上,随访1年以内死亡。结果:我们根据医疗记录和死亡证明确定了510名受试者,其中360人的痴呆诊断符合入组标准。在51例诊断为DLB的患者中,23例患者服用过DNP, 28例患者由于在1999年日本引入DNP之前的治疗而未接受药物治疗。DNP组和非DNP组发病后预期寿命分别为6.4年和3.6年;具有显著的药物效果。然而,与之前的AD数据相比,没有注意到SNH居住的显著影响。结论:尽管本报告的局限性是所有分析都是回顾性的,缺乏随机化,但我们发现DNP对DLB发病后的预期寿命有积极影响。与AD相比,DLB的预期寿命较低,且SNH居住的影响不足,这表明DLB的胆碱能缺乏程度大于AD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lifetime Expectancy in Dementia with Lewy Bodies: Effects of Donepezil Administration and Special Nursing Home Replacement. A Retrospective Analysis in the Tajiri Project
Objective: Cholinesterase inhibitors (ChEIs) can delay the progression of Alzheimer disease (AD). We previously demonstrated a positive effect of donepezil (DNP) administration and a Special Nursing Home (SNH) replacement on lifetime expectancy after the onset of AD. Recently DNP has been indicated for use in the treatment of dementia with Lewy Bodies (DLB); however, the effect on lifetime expectancy remains unclear. Herein, we analyzed the effects of DNP on DLB. Methods: All outpatients at the Tajiri Clinic with available medical records and death certificates from 1999- 2012 were included in this retrospective analysis. The entry criteria were a diagnosis of dementia based on DSM-IV criteria and diagnosis of DLB using the international consensus criteria; medical treatment for more than 3 months and follow up to less than 1 year before death. Results: We identified 510 subjects based upon medical records and death certificates, of which 360 had a diagnosis of dementia that met the entry criteria. Of 51 patients diagnosed with DLB, 23 had taken DNP and 28 patients had not undergone drug treatment due to treatment prior to the introduction of DNP in 1999 in Japan. The lifetime expectancies after onset were 6.4 years in the DNP group and 3.6 years in the non-DNP group; with a significant drug effect. However, in contrast with the previous AD data, no significant effect of SNH residency was noted. Conclusion: Although this report has the limitation that all analyses were retrospective and lacked randomization, we found a positive effect of DNP on lifetime expectancy after the onset of DLB. The lower life expectancy compared with that of AD and the lack of an effect of SNH residency suggest the cholinergic deficiency in DLB is greater than that in AD.
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