CCL17作为一种新的治疗靶点在病理性心肌肥厚和心力衰竭中发挥作用

The Tokushima journal of experimental medicine Pub Date : 2022-06-10 DOI:10.1084/jem.20200418

Yang Zhang, Y. Ye, Xiaoqiang Tang, Hui Wang, Toshiko Tanaka, R. Tian, Xufei Yang, Lun Wang, Ying Xiao, Xiaomin Hu, Ye Jin, H. Pang, Tian Du, Honghong Liu, Lihong Sun, Shuo Xiao, R. Dong, L. Ferrucci, Z. Tian, Shuyang Zhang

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引用次数: 14

摘要

Zhang等人通过调节T细胞的可塑性和分化，发现趋化因子CCL17是人类和小鼠与年龄相关的心力衰竭的一个因素。他们的研究结果表明，CCL17是一种治疗老年性心力衰竭的新靶点。

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CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure

Zhang et al. identified chemokine CCL17 as a contributor to age-related heart failure in humans and mice via regulating plasticity and differentiation of T cells. Their findings suggested CCL17 as a novel therapeutic target in age-related heart failure.

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The Tokushima journal of experimental medicine

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