{"title":"影响姜黄素- al (III)配合物形成的因素","authors":"A. M. Rawa'a, N. Tariq, S. Wisam","doi":"10.15228/2015.v05.i01.p05","DOIUrl":null,"url":null,"abstract":"Curcumin has been recognized as a potential natural drug to treat the Alzheimer’s disease (AD) by chelating metal ions. In the present paper, curcumin–Al (III) [Cur - Al (III)] complexes were synthesized in aqueous solution and characterized by UV-visible spectroscopy. The formation of complexes between Al (III) and curcumin in acidic condition, by using citric acid as catalyst were studied. The complex molar ratio [Cur - Al (III] was found to be 2:1 in buffer phosphate of pH 1.0, 1.5, 2.0, 3.0, 3.5 and 4.0. The optimum pH for the complex [Cur - Al (III)] formation was at phosphate buffer of pH=2.5, at this pH the complex [Cur. - Al (III)] was more stable than the other pH values (throughout the absorbance calculation at 531nm). About 92% of Al (III) was chelated by curcumin at pH 2.5 as compared with 1.0, 1.5, 2.0, 3.0, 3.5 and 4.0 pH values. Curcumin complexes (at pH 2.5) were thermally stable at 100 o C as compared with 75, 50 and 25 o C respectively. The chemical shifts of spectrum shows that the curcumin was","PeriodicalId":19815,"journal":{"name":"Pakistan Journal of Chemistry","volume":"32 1","pages":"30-35"},"PeriodicalIF":0.0000,"publicationDate":"2015-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"The Factors Effecting the Formation of Curcumin-Al (III) Complexes\",\"authors\":\"A. M. Rawa'a, N. Tariq, S. Wisam\",\"doi\":\"10.15228/2015.v05.i01.p05\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Curcumin has been recognized as a potential natural drug to treat the Alzheimer’s disease (AD) by chelating metal ions. In the present paper, curcumin–Al (III) [Cur - Al (III)] complexes were synthesized in aqueous solution and characterized by UV-visible spectroscopy. The formation of complexes between Al (III) and curcumin in acidic condition, by using citric acid as catalyst were studied. The complex molar ratio [Cur - Al (III] was found to be 2:1 in buffer phosphate of pH 1.0, 1.5, 2.0, 3.0, 3.5 and 4.0. The optimum pH for the complex [Cur - Al (III)] formation was at phosphate buffer of pH=2.5, at this pH the complex [Cur. - Al (III)] was more stable than the other pH values (throughout the absorbance calculation at 531nm). About 92% of Al (III) was chelated by curcumin at pH 2.5 as compared with 1.0, 1.5, 2.0, 3.0, 3.5 and 4.0 pH values. Curcumin complexes (at pH 2.5) were thermally stable at 100 o C as compared with 75, 50 and 25 o C respectively. The chemical shifts of spectrum shows that the curcumin was\",\"PeriodicalId\":19815,\"journal\":{\"name\":\"Pakistan Journal of Chemistry\",\"volume\":\"32 1\",\"pages\":\"30-35\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-03-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pakistan Journal of Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15228/2015.v05.i01.p05\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Journal of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15228/2015.v05.i01.p05","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
姜黄素被认为是一种通过螯合金属离子治疗阿尔茨海默病(AD)的潜在天然药物。本文在水溶液中合成了姜黄素- Al (III) [Cur - Al (III)]配合物，并用紫外可见光谱对其进行了表征。以柠檬酸为催化剂，研究了Al (III)与姜黄素在酸性条件下的配合物形成。在pH为1.0、1.5、2.0、3.0、3.5和4.0的缓冲磷酸盐中，[Cur - Al (III)]的络合物摩尔比为2:1。在pH=2.5的磷酸盐缓冲液中形成络合物[Cur. - Al (III)]的最佳pH值，在该pH值下，络合物[Cur. - Al (III)]比其他pH值更稳定(整个531nm吸光度计算)。与1.0、1.5、2.0、3.0、3.5和4.0的pH值相比，姜黄素在pH为2.5时对Al (III)的螯合率约为92%。姜黄素配合物(pH为2.5)在100℃时的热稳定性分别高于75℃、50℃和25℃。光谱的化学位移表明姜黄素为
The Factors Effecting the Formation of Curcumin-Al (III) Complexes
Curcumin has been recognized as a potential natural drug to treat the Alzheimer’s disease (AD) by chelating metal ions. In the present paper, curcumin–Al (III) [Cur - Al (III)] complexes were synthesized in aqueous solution and characterized by UV-visible spectroscopy. The formation of complexes between Al (III) and curcumin in acidic condition, by using citric acid as catalyst were studied. The complex molar ratio [Cur - Al (III] was found to be 2:1 in buffer phosphate of pH 1.0, 1.5, 2.0, 3.0, 3.5 and 4.0. The optimum pH for the complex [Cur - Al (III)] formation was at phosphate buffer of pH=2.5, at this pH the complex [Cur. - Al (III)] was more stable than the other pH values (throughout the absorbance calculation at 531nm). About 92% of Al (III) was chelated by curcumin at pH 2.5 as compared with 1.0, 1.5, 2.0, 3.0, 3.5 and 4.0 pH values. Curcumin complexes (at pH 2.5) were thermally stable at 100 o C as compared with 75, 50 and 25 o C respectively. The chemical shifts of spectrum shows that the curcumin was
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