迷迭香提取物改善镉诱导的白化大鼠肝脏组织学改变和氧化损伤

IF 1.1 Q3 BIOLOGY
S.A. Sakr, M.F. Bayomy, A.M. El-Morsy
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引用次数: 33

摘要

研究了镉暴露大鼠肝脏的氧化损伤和组织学变化,以及迷迭香提取物对镉肝毒性的改善作用。结果表明,与对照组相比,Cd (30 mg/kg b.w,连续5天/周,连续8周)可导致MDA水平升高,SOD、CAT活性和GSH浓度降低。相比之下,迷迭香水提取物使这些参数的变化恢复到接近正常水平。用Cd治疗动物会导致不同的组织病理变化,如肝细胞正常结构的丧失、血液充血、白细胞浸润和脂肪变性。超微结构结果显示细胞核异常,线粒体肿胀,内质网变性,溶酶体增多,脂肪滴出现。另一方面,用Cd和迷迭香治疗的动物在这些变化方面有所改善,组织结构看起来正常。结果表明,迷迭香提取物的改善作用可能与其抗氧化作用有关,其抗氧化作用可能与自由基诱导的氧化应激和氯化镉所致的组织损伤有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rosemary extract ameliorates cadmium-induced histological changes and oxidative damage in the liver of albino rat

The oxidative damage and histological changes of liver of rats exposed to cadmium and the ameliorative effect of rosemary extract against cadmium hepatotoxicity were studied. The results showed that exposure to Cd (30 mg/kg b.w., 5 consecutive days/week for 8 weeks) led to an increase in the MDA levels and a decrease in activity of SOD, CAT and the concentration of GSH versus controls. In contrast, administration of rosemary aqueous extract restored the changes in these parameters to nearly the normal levels. Treating animals with Cd led to different histopathological changes such as loss of the normal structure of hepatic cells, blood congestion, leukocytic infiltrations and fatty degeneration. Ultra structure results revealed abnormality in the nucleus, swelling of mitochondria, degeneration of endoplasmic reticulum, and increase of lysosomes and appearance of fat droplets. On the other hand, animals treated with Cd and rosemary showed an improvement in these changes and the tissue appears with normal structures. The results suggested that the ameliorative effect of rosemary extract may be due to its antioxidant properties in combating free radical-induced oxidative stress and tissue injury resulting from cadmium chloride.

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