幽门螺杆菌感染与儿童特发性血小板减少性紫癜。

Kuan-Sheng Wu, C. Hsiao, Hong-Ren Yu, E. Huang, Wanqi Mai, J. Sheen
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引用次数: 14

摘要

几项研究显示,一些慢性特发性血小板减少性紫癜(ITP)患者在根除幽门螺杆菌(h.p ylori)后血小板完全恢复,并将持续血小板减少症的原因归结为无法根除幽门螺杆菌。因此,我们研究了儿童ITP患者诊断时的幽门螺杆菌感染情况,并探讨幽门螺杆菌感染是否在儿童ITP的发展中起作用。方法比较2004年9月至2006年6月诊断为ITP的32例儿童ITP患者与30例未选择的无血小板减少史的对照组在一个月内连续出现咽扁桃体炎、支气管炎或支气管肺炎的临床表现,通过粪便幽门螺杆菌抗原检测比较其感染情况。我们进一步分析了幽门螺杆菌感染阳性(H. pylori(+))和幽门螺杆菌感染阴性(H. pylori(-))儿童ITP患者之间的参数。结果研究组幽门螺杆菌阳性(H. pylori +)率为19%,对照组为17%,差异无统计学意义。在幽门螺杆菌状态的特点及治疗反应方面,两组间也无统计学差异。虽然幽门螺杆菌阳性组(2/6)比幽门螺杆菌阴性组(3/26)倾向于慢性ITP,但差异无统计学意义。结论本研究认为幽门螺杆菌感染在儿童ITP的发展中起次要作用。为了进一步证实幽门螺杆菌感染与儿童ITP发展之间的关系,需要进行大规模的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Helicobacter pylori infection and childhood idiopathic thrombocytopenic purpura.
BACKGROUND Several studies showed some chronic idiopathic thrombocytopenic purpura (ITP) patients with complete platelet recovery after Helicobacter pylori (H. pylori) eradication and cited the cause of persistent thrombocytopenia as inability to eradicate H. pylori. So we studied H. pylori infection status in pediatric ITP patients at diagnosis and address whether such infection played a role in the development of childhood ITP. METHODS We compared H. pylori infection status by stool H. pylori antigen test of an ITP group including 32 childhood ITP patients at diagnosis from September 2004 to June 2006 and a control group including 30 unselected patients with no history of thrombocytopenia seen consecutively with clinical manifestations of pharyngotonsillitis, bronchitis, or bronchopneumonia in our ward during a one-month span. We further analyzed parameters between H. pylori infection-positive (H. pylori(+)) and H. pylori infection-negative (H. pylori(-)) childhood ITP patients. RESULTS The H. pylori-positive (H. pylori(+)) rate was 19% in the study group and 17% in the control group, with not statistically significant difference. As for the characteristics and treatment response about H. pylori status, they were also not statistically different. Although the ratio of chronic ITP cases showed higher tendency in H. pylori(+) patients (2/6) than the H. pylori(-) ones (3/26), it was not statistically significant. CONCLUSIONS It seems that H. pylori infection played a minor role in the development of childhood ITP in this small-scale study. A large-scale study is necessary to further confirm the relationship between H. pylori infection and the development of childhood ITP.
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