新型抗菌药物的鉴定——药用植物银叶提取物体外抑菌和抗真菌活性的研究汁液。Schult交货

Madhusudhan Kairamkonda, Vikram Godishala, V. Kandi
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引用次数: 0

摘要

在对大多数常规治疗中使用的抗菌剂表现出耐药性的微生物引起的传染病存在和传播的时代,迫切需要寻找可用作抗菌剂的潜在药物。采用标准的提取工艺对水藻植物提取物进行了提取和处理。然后用不同浓度的植物提取物浸渍Whatman滤纸,采用Kirby-Bauer圆盘扩散法对细菌进行抗菌药敏试验。采用标准盘片扩散法测定了抗真菌药物对酵母菌和非皮肤真菌丝状真菌分离株的抑制作用。浓度为600µg/ mL和900µg/ mL的乙醇提取物对大肠杆菌的抑菌活性比相同浓度的标准药物增强。氯仿提取物和乙醇提取物对肺炎克雷伯菌的抗菌活性增强。氯仿溶剂提取物对白色念珠菌的抑菌活性与标准药物相似,水提取物对卤化Drechslera halodes的抑菌活性高于对照药物。与对照药物相比,紫叶雀叶提取物的抑菌和抗真菌活性相似或增加,表明其有潜力成为未来的候选抗菌药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification of Newer Antimicrobial Agents: A Study of Invitro Antibacterial and Antifungal Activities of Leaf extracts of Medicinal Plant Aerva lanata (L.) Juss. ex Schult
In the era of presence and spread of infectious diseases caused by microorganisms demonstrating resistance against most antimicrobial agents routinely used in the treatment, there is a serious need of search for potential agents which can be used as antimicrobials. The plant extracts of Aerva lanata were collected and processed using standard procedures. Whatman filter papers were then impregnated with varied concentrations of plant extract and antimicrobial susceptibility testing was performed using Kirby-Bauer disk diffusion method for bacteria. The standard disk diffusion method was used to test antifungal drugs against yeasts, and non-dermatophyte filamentous fungal isolates.The ethanolic extract at a concentration of 600 µg/ mL and 900 µg/ mL showed increased antibacterial activities against Esherichia coli as compared to the standard drug tested at similar concentrations. The chloroform extracts and the ethanol extract revealed increased antibacterial activity against Klebsiella pneumoniae. The chloroform solvent extract showed similar antifungal activities as the standard drug against Candida albicans, and the H2O extract showed greater antifungal activity against Drechslera halodes as compared to the control drug tested. Antibacterial and antifungal properties of leaf extracts of Aerva lanata plant in comparison with the control drugs revealed either similar or increased activities signifying their potential for future candidates as antimicrobial agents.
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