衰老、表型和碳水化合物饲喂对LA/Ntul//-cp(肥胖)大鼠热效率和肥胖的影响

O. Tulp
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引用次数: 6

摘要

LA/Ntul//-cp(肥胖)特异性无病原体大鼠品系在5至6周龄时出现肥胖表型。雌性先天性瘦肉和肥胖LA/Ntul//-cp(肥胖)大鼠组[n=12 -20只大鼠/表型]在4、14或24个月时随意饲喂标准Purina日粮,或从12周龄开始饲喂同样的日粮加16% (w/v)蔗糖溶液,并测定每个年龄组的体重、热量摄入和热量效率(CE)。瘦仔鼠的体重在所有研究年龄都保持相似,而肥胖表型的体重在每个研究年龄都明显大于瘦仔鼠。在所有年龄的研究中,蔗糖补充对瘦型的最终体重没有显著影响(p= 0.05),但与肥胖型的4、14和24月龄的较大体重相关(p=<0.05)。在整个年龄范围内,瘦肉动物每天卡路里/克体重的比率保持相对恒定,因此确定了CE,但CE在所有年龄的肥胖表型中都更有效,并且随着年龄的增长,补充蔗糖的效率逐渐提高。本研究结果表明,CE与该菌株肥胖表型中肥胖发展的易感性相关,并且可能涉及多种代谢因素,这些代谢因素有助于该菌株中肥胖的能量利用和/或能量节约效率高于瘦表型。添加蔗糖的代谢影响与这种遗传啮齿类动物肥胖表型中体重增加和肥胖的附加影响相关
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Effects of aging, phenotype and carbohydrate feeding on caloric efficiency and adiposity in the LA/Ntul//-cp (corpulent) rat
Obesity develops in the obese phenotype of the LA/Ntul//-cp (corpulent) specific pathogen-free rat strain by 5 to 6 weeks of age. Groups [n=12 -20 rats/phenotype] of female congenic lean and obese LA/Ntul//-cp (corpulent) rats were fed ad libitum standardized Purina diets for 4, 14, or 24 months or the same diet plus a 16% (w/v) sucrose solution supplement from 12 weeks of age, and measures of body weight, caloric intake, and caloric efficiency (CE) determined at each age group. Body weights of lean animals remained similar at all ages studied, while body weights of obese phenotype were significantly greater than their lean littermates at each age studied. The sucrose supplement was without significant effect on final body weights in the lean phenotypes at all ages studied (p=n.s.) but were associated with greater body weights at ages 4, 14 and 24 months of age in the obese phenotype (p=<0.05). CE was determined as the ratio of kcal/gram of body weight per day remained relatively constant in lean animals throughout the age range, but CE was more efficient in the obese phenotype at all ages studied and became progressively more efficient with the sucrose supplement feeding with increasing age. The results of this study indicate that CE is associated with the predisposition for the development of obesity in the obese phenotype of this strain and likely implicates multiple metabolic factors that contribute to a greater efficiency of energy utilization and or energy conservation in the obese than in the lean phenotype of this strain, and the metabolic impact of added sucrose was associated with an additive impact on the CE of weight gain and adiposity in the obese phenotype of this congenic rodent strain
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