局部替诺昔康和双氯芬酸治疗膝骨关节炎的疗效和安全性的前瞻性比较随机试验

N. Kashevarova, E. Taskina, E. Strebkova, E. Sharapova, N. Savushkina, T. Korotkova, L. Alekseeva, A. Lila
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引用次数: 0

摘要

局部形式的非甾体抗炎药(NSAIDs)的特点是由于低全身吸收而具有很高的安全性。它们不会增加发生特定类别胃肠道、心血管和肾脏不良事件(ae)的风险,这使得即使在严重的共病病理(这是骨关节炎(OA)患者的典型症状)中也可以开处方。目的:在一项前瞻性比较随机试验中,评价1%阿洛尚凝胶(替诺昔康)与1%双氯芬酸凝胶在膝关节OA患者中的疗效和安全性。材料和方法。该研究包括60例Kellgren-Lawrence II-III期膝关节OA患者,年龄41至78岁。患者随机分为两组:第一组给予1% Artoxan凝胶,5 cm,每日2次,连用14 d;2 -双氯芬酸凝胶1%按相同方案。在治疗期间,我们使用视觉模拟量表评估疼痛,使用WOMAC指数,使用EQ-5D问卷评估生活质量,对治疗的满意度和效果时间。结果和讨论。研究表明,局部形式的非甾体抗炎药对OA的所有临床表现都有积极作用:有效减轻疼痛,僵硬,改善关节功能状态和生活质量。它们还具有良好的安全性和快速的症状反应。两组比较表明,局部剂型替诺昔康的患者有更快、更明显的镇痛效果。研究结果证实了局部形式的非甾体抗炎药的良好疗效和安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A prospective comparative randomized trial of the efficacy and safety of topical tenoxicam and diclofenac in knee osteoarthritis
Local forms of non-steroidal anti-inflammatory drugs (NSAIDs) are characterized by a high safety profile due to low systemic absorption. They do not increase the risk of developing class-specific gastrointestinal, cardiovascular and kidney adverse events (AEs), which makes it possible to prescribe them even in severe comorbid pathology, which is typical for patients with osteoarthritis (OA).Objective: to evaluate the efficacy and safety of Artoxan gel (tenoxicam) 1% in comparison with Diclofenac gel 1% in patients with knee OA in a prospective comparative randomized trial.Material and methods. The study included 60 patients with Kellgren–Lawrence stages II–III knee OA, aged 41 to 78 years. The patients were randomly divided into two groups: the 1st group received Artoxan gel 1%, 5 cm 2 times a day for 14 days; 2nd – Diclofenac gel 1% according to the same scheme. During therapy, we assessed pain using a visual analog scale, the WOMAC index, quality of life using the EQ-5D questionnaire, satisfaction with therapy, and time to effect.Results and discussion. It has been demonstrated that local forms of NSAIDs have a positive effect on all clinical manifestations of OA: effectively reduce pain, stiffness, improve the functional state of the joints and quality of life. They also have a good safety profile and a fast symptomatic response. Comparison of the two groups showed that in patients receiving the local form of tenoxicam, there was a tendency to a more rapid and pronounced analgesic effect.Conclusion. The results of the study confirm the good efficacy and safety of local forms of NSAIDs. 
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