瓜石榴番石榴对大肠杆菌、金黄色葡萄球菌、沙门氏菌和链球菌临床分离株抑菌活性优化新策略

Mathew Gideon
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摘要

开发一种新的抗生素是一项具有挑战性的任务,估计失败率为95%。药物化学结构的微小变化,如立体化学、几何结构或官能团修饰,可显著影响其药物活性。在本研究中,我们旨在设计新的策略,通过简单的反应来优化番石榴叶提取物的抗菌性能,无论是自反应还是与试剂、药物或不同植物提取物的联合反应。傅里叶变换红外光谱分析发现,制备的番石榴(GG)和番石榴阿司匹林(GAG)样品中共轭并形成了新的官能团,并通过重量分析进一步证实了这一点。结果表明,通过简单的反应可以提高或优化药用植物的抗菌活性,如将植物提取物与非抗菌药物(如阿司匹林)联合使用,或在100 - 110℃的温度范围内加热加入少量浓硫酸。在两种组合方法中,GG在浓度为0.1 mg/mL时对所有被试菌株的生长均有较好的抑制作用,而GAG在相同浓度下仅对两种菌株的生长有抑制作用:这些方法可以进一步探索和应用于各种研究,包括抗真菌、抗炎、抗病毒和抗癌研究,利用药用植物中天然产物的可获得性和多样性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Novel Strategy for Optimizing the Antibacterial Activity of Psidium guajava Against Clinical Isolates of Escherichia coli, Staphylococcus aureus, Salmonella spp., and Streptococcus spp.
The development of a new antibiotic is a challenging task, with an estimated failure rate of 95%. Minor changes in the chemical structure of a drug, such as stereochemistry, geometry, or functional group modifications, can significantly impact its medicinal activity. In this study, we aim to devise novel strategies for optimizing the antimicrobial properties of guava leaf extract through simple reactions, either by self-reaction or combination reactions with a reagent, drug, or different plant extract. Fourier transform infrared spectroscopy analysis revealed conjugation and formation of new functional groups in the prepared sample of Guava Guava (GG) and Guava Aspirin Guava (GAG), which were further confirmed by weight analysis. The results demonstrated that the antimicrobial activity of medicinal plants can be improved or optimized through simple reactions, such as combining the plant extract with a non-antimicrobial drug like aspirins or adding a small volume of concentrated sulfuric acid to the plant extract by heating at a temperature range of 100 – 110°C. Among the two combinatory methods used, GG exhibited better performance in inhibiting the growth of all tested bacterial strains at a concentration of 0.1 mg/mL compared to GAG at the same concentration, which inhibited the growth of only two bacterial strains: Escherichia coli and Streptococcus spp. These methods can be further explored and applied in various studies, including antifungal, anti-inflammatory, antiviral, and anticancer research, leveraging the availability and diverse range of natural products found in medicinal plants.
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