在伍德沃德-霍夫曼规则的前沿演奏

C. López
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引用次数: 0

摘要

周环反应以其精细的选择性和在许多情况下具有高度控制的多个手性中心的形成而闻名。随着精确计算工具的出现,这种控制被转化为可预测性,这一系列反应的设计和开发开启了有机合成的新时代。突然间,在相对较短的反应序列中可以获得高度复杂和大量修饰的多环结构。我们对探索控制这些反应的规则的应用限制的兴趣使我们发现了一系列令人大开眼界的过渡后效应,这些效应是最终在微观水平上理解反应性的关键。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
PLAYING IN THE FRONTIERS OF THE WOODWARD-HOFFMANN RULES
Pericyclic reactions are known for their exquisite selectivity and, in many cases, the formation of multiple chiral centers with a high degree of control. With the advent of accurate computational tools, this control was translated into predictability, and the design and exploitation of this set of reactions opened a new era in organic synthesis. Suddenly, highly complex and profusely decorated polycyclic structures were accessible in relatively short reaction sequences. Out interest in exploring the limits of application of the rules that govern these reactions with ironfist led us to discover a range of eye opening post-transitional effects that are key to ultimately understand reactivity at a microscopic level.
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