幽门螺杆菌的前景

S. Elakkiya, R. S. Kumar, N. Venkateswaramurthy
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引用次数: 0

摘要

幽门螺杆菌(Helicobacter pylori, H. pylori)是一种革兰氏阴性菌,其感染在人群中非常普遍,可导致胃肠道相关疾病(胃和十二指肠溃疡、粘膜相关组织淋巴瘤和胃腺癌)。大多数幽门螺旋杆菌感染的人不会有任何体征或症状。虽然这种细菌感染了世界50%的人口,但在非洲,由于感染是在儿童时期获得的,其流行率高达80%。由于抗菌素耐药性的增加,幽门螺杆菌根除治疗变得越来越具有挑战性。治疗方案有望克服日益流行的耐药幽门螺杆菌菌株,并实现>90%的根除率。虽然治疗方案提供了可接受的幽门螺杆菌根除率,但所使用的方案应有助于幽门螺杆菌对抗菌剂和其他治疗的未来耐药性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prospectives of Helicobacter pylori
Helicobacter pylori (H. pylori) is a gram negative bacteria whose infection is highly prevalent among the human population and leads to gastrointestinal tract related diseases (gastric and duodenal ulcers, mucosa associated tissue lymphoma and gastric adenocarcinoma). Most people with H. pylori infection will never have any signs or symptoms. While this bacterium infects 50% of the world’s population, in Africa its prevalence reach as high as 80% as the infection is acquired during childhood. H. pylori eradication treatment is becoming more challenging due to increasing antimicrobial resistance. Treatment regimens are expected to overcome the increasing prevalence of resistant strains of H. pylori and achieve a >90% eradication rate. Although treatment regimens provide acceptable H. pylori eradication rates, the regimens used should contribute to future resistance of H. pylori to antimicrobials and other therapies.
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