两种广谱SPF 15防晒霜对紫外线引起的人类延迟型超敏反应的抑制提供不同的保护

D. Moyal
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摘要

防晒霜是用来防止晒伤的,其功效由所谓的防晒系数(SPF)来表示。然而,该指数可能不足以提供对紫外线引起的其他生物损伤(如免疫抑制)的保护的相关测量。我们在人类志愿者中测量了两种具有不同UVA防护水平的广谱SPF 15防晒霜在急性太阳模拟紫外线照射后防止局部延迟型超敏反应(DTH)对召回抗原(Multitest Pasteur/Merieux)的反应下降的能力。我们首先确定了不同组15名志愿者显著降低DTH反应所需的uvr剂量。最小红热剂量(MED)为最小免疫抑制剂量。该剂量诱导免疫DTH应答平均下降36%。低剂量试验(0.5和1 MED)无效。防晒霜处理组暴露于等于2 MED × SPF产品的剂量。在使用具有最高UVA保护的产品的组中,DTH反应并未降低。相反,在使用低UVA防护防晒霜的组中,DTH反应显着降低了55.7%。这些数据表明,防晒系数可能不足以预测防晒霜保护免疫系统的能力。测量UVA的保护也可能是必要的,因为UVA似乎对红斑的贡献很低,但强烈影响免疫反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
015 Two broadspectrum SPF 15 sunscreens offer different protection against UV induced depression of delayed type hypersensitivity response in humans
Sunscreens are designed to protect against sunburn and their efficacy is indicated by the so-called sun protection factor (SPF). However this index may be inadequate to provide a relevant measurement of protection against other biological damages induced by UV such as immunosuppression. We measured in human volunteers the ability of two broad spectrum SPF 15 sunscreens, with different UVA protection levels, to prevent the fall in local delayed type hypersensitivity (DTH) response to recall antigens (Multitest Pasteur/Merieux) after acute solar simulated UV exposure. We first determined the UVR-dose needed to induce a significant reduction of DTH response in different groups of 15 volunteers. Two minimal erythernal dose (MED) were found to be the minimal immunosuppressive dose. This dose induced a 36% average fall in immune DTH response. The lower doses tested (0.5 and 1 MED) were ineffective. Sunscreen treated groups were exposed to a dose equal to 2 MED × SPF of the products. The DTH response was not lowered in the group treated by the product having the highest UVA protection. Conversely the DTH response was significantly reduced by 55.7% in the group treated with the low UVA protection sunscreen. These data suggest that sun protection factor may not be sufficient to predict the ability of sunscreens to protect the immune system. A measurement of UVA protection may also be necessary as UVA seems to have a low contribution to erythema but strongly affects immune response.
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