S. Blanco Dorado, O. Maroñas, Ana Latorre-Pellicer, Teresa Rodríguez Jato, Ana López-Vizcaíno, Áurea María Gómez Márquez, B. Bardán García, Dolores Belles Medall, G. Barbeito Castiñeiras, M. L. Pérez Del Molino Bernal, M. Campos‐Toimil, F. O. Otero Espinar, Andrés Blanco Hortas, G. Durán Piñeiro, I. Zarra Ferro, Á. Carracedo, M. Lamas, A. Fernández-Ferreiro
{"title":"CYP2C19基因型和药物相互作用对伏立康唑血药浓度的影响:一项西班牙药物遗传-药代动力学前瞻性多中心研究","authors":"S. Blanco Dorado, O. Maroñas, Ana Latorre-Pellicer, Teresa Rodríguez Jato, Ana López-Vizcaíno, Áurea María Gómez Márquez, B. Bardán García, Dolores Belles Medall, G. Barbeito Castiñeiras, M. L. Pérez Del Molino Bernal, M. Campos‐Toimil, F. O. Otero Espinar, Andrés Blanco Hortas, G. Durán Piñeiro, I. Zarra Ferro, Á. Carracedo, M. Lamas, A. Fernández-Ferreiro","doi":"10.1002/phar.2351","DOIUrl":null,"url":null,"abstract":"Voriconazole, a first‐line agent for the treatment of invasive fungal infections, is mainly metabolized by cytochrome P450 (CYP) 2C19. A significant portion of patients fail to achieve therapeutic voriconazole trough concentrations, with a consequently increased risk of therapeutic failure.","PeriodicalId":19812,"journal":{"name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":"{\"title\":\"Impact of CYP2C19 Genotype and Drug Interactions on Voriconazole Plasma Concentrations: A Spain Pharmacogenetic‐Pharmacokinetic Prospective Multicenter Study\",\"authors\":\"S. Blanco Dorado, O. Maroñas, Ana Latorre-Pellicer, Teresa Rodríguez Jato, Ana López-Vizcaíno, Áurea María Gómez Márquez, B. Bardán García, Dolores Belles Medall, G. Barbeito Castiñeiras, M. L. Pérez Del Molino Bernal, M. Campos‐Toimil, F. O. Otero Espinar, Andrés Blanco Hortas, G. Durán Piñeiro, I. Zarra Ferro, Á. Carracedo, M. Lamas, A. Fernández-Ferreiro\",\"doi\":\"10.1002/phar.2351\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Voriconazole, a first‐line agent for the treatment of invasive fungal infections, is mainly metabolized by cytochrome P450 (CYP) 2C19. A significant portion of patients fail to achieve therapeutic voriconazole trough concentrations, with a consequently increased risk of therapeutic failure.\",\"PeriodicalId\":19812,\"journal\":{\"name\":\"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/phar.2351\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/phar.2351","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Impact of CYP2C19 Genotype and Drug Interactions on Voriconazole Plasma Concentrations: A Spain Pharmacogenetic‐Pharmacokinetic Prospective Multicenter Study
Voriconazole, a first‐line agent for the treatment of invasive fungal infections, is mainly metabolized by cytochrome P450 (CYP) 2C19. A significant portion of patients fail to achieve therapeutic voriconazole trough concentrations, with a consequently increased risk of therapeutic failure.
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