Clinical manifestations of decreased ovarian reserve in premenopausal women: a cross-sectional study

Abstract: The objective of the study was to estimate the prevalence and clinical manifestation of decreased ovarian reserve in women of reproductive age from Eastern Siberia Methods and Results: During a cross-sectional study, performed in 2017-2019 in Irkutsk Region and Buryat Republic (Russia), we invited 1119 women aged 18 to 40 yrs, who underwent an annual preventive medical examination at their place of work. Of 1119 women, 907 women aged 31,78 5,13 years were included in the study. We used clinical, instrumental, and laboratory research methods and statistical analysis. Of the 907 women included in the study, 117 participants 12.9% had a follicle number per ovary of less than 5 and were diagnosed as patients with decreased ovarian reserve (DOR). According to the laboratory study, 56 out of 117 (47.8%) AMH was below 1.2 ng/ml. The average value of which was 0.53 0.43 ng/ml. In women with reduced AMH levels, a shortening of the menstrual cycle and high parity were observed. Also, in 4 of 117 (3,4%) patients with a reduced number of antral follicles, premature ovarian failure was diagnosed. Conclusion: Determination of ovarian reserve by one AFC parameter may be useful for determining the risk group of women with premature ovarian insufficiency.