Studying the protective role of resveratrol against D-galactose-induced renal damage in male albino rats

Background: Chronic kidney disease is a significant global health issue with a sharply rising incidence, although modern medicine has made enormous strides, there are still several limitations to kidney disease prevention and therapy. The objective of this research was to investigate resveratrol's potential protective results against d-galactose-induced kidney injury in male albino rats. Methods: Forty adult male albino rats were used in this study (weighing 150 – 200 g). All rats were split into four equal groups, as follows: group I (Control group): injected with 0.9% saline subcutaneously every day for eight weeks, group II (D-gal group): received 120 mg/kg D‐gal in 0.9% saline subcutaneously every day for eight weeks, group III (Res group): received resveratrol at a dose of (50 mg/kg/day) dissolved in saline 0.9 % via oral gavage for eight weeks, group IV (D-gal + Res group): received D-gal subcutaneously and oral resveratrol daily for eight weeks in the same doses as in groups II and III. Results: group II (D-gal group) demonstrated significant rise in serum creatinine level, BUN, TNF-α level and renal MDA level with significant drop in renal GPx level while group IV (D-gal + Res) revealed significant decline in serum creatinine, BUN, TNF-α and renal MDA levels with significant increase in the renal GPx level. Conclusions: Resveratrol effectively protects the kidney tissues against d-galactose-induced injury in aging rats.